Accession ARO:3005058
DefinitionABC transporter complex which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classglycopeptide antibiotic, oxazolidinone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class oxazolidinone antibiotic [Drug Class]
+ confers_resistance_to_antibiotic vancomycin [Antibiotic]
2 ontology terms | Show
+ mlaD part_of
+ mlaF part_of

Malinverni JC, et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106(19):8009-14 An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. (PMID 19383799)

Thong S, et al. 2016. Elife 5: Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. (PMID 27529189)

Rundell EA, et al. 2020. J. Bacteriol. 202(6): A Screen for Antibiotic Resistance Determinants Reveals a Fitness Cost of the Flagellum in Pseudomonas aeruginosa. (PMID 31871033)