Accession ARO:3005040
CARD Short NameYajC
DefinitionYajC interacts with the AcrAB-TolC efflux pump in a way that in uncharacterized but is shown to grant increased fitness in the presence of linezolid, rifampicin, and vancomycin.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, disinfecting agents and antiseptics, rifamycin antibiotic, glycylcycline, cephalosporin, penam, phenicol antibiotic, oxazolidinone antibiotic, fluoroquinolone antibiotic, glycopeptide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesPseudomonas aeruginosag+wgs, Pseudomonas fluorescensg
Resistomes with Sequence VariantsPseudomonas aeruginosag+wgs, Pseudomonas brassicacearumwgs, Pseudomonas chlororaphiswgs, Pseudomonas fluorescensg+wgs, Pseudomonas monteiliig+wgs, Pseudomonas putidag+wgs
Classification26 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ subunit of efflux pump conferring antibiotic resistance
+ participates_in AcrAB-TolC
+ confers_resistance_to_antibiotic linezolid [Antibiotic]
+ confers_resistance_to_antibiotic rifampin [Antibiotic]
+ confers_resistance_to_antibiotic vancomycin [Antibiotic]

Rundell EA, et al. 2020. J. Bacteriol. 202(6): A Screen for Antibiotic Resistance Determinants Reveals a Fitness Cost of the Flagellum in Pseudomonas aeruginosa. (PMID 31871033)


Prevalence of YajC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Pseudomonas aeruginosa100%0%68.16%0%
Pseudomonas brassicacearum0%0%4%0%
Pseudomonas chlororaphis0%0%3.23%0%
Pseudomonas fluorescens2.78%0%1.74%0%
Pseudomonas monteilii55.56%0%45.24%0%
Pseudomonas putida21.13%0%14.97%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 200

>gb|TKW44661.1|+|YajC [Pseudomonas aeruginosa]

>gb|VAOQ01003483.1|+|1-339|YajC [Pseudomonas aeruginosa]