| Accession | ARO:3003746 |
| CARD Short Name | optrA |
| Definition | OptrA is a member of the ABC-F protein subfamily that confers resistance to oxazolidinones. The gene encoding the protein was originally isolated from a plasmid in Enterococcus faecalis and Enterococcus faecium. |
| AMR Gene Family | Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins |
| Drug Class | phenicol antibiotic, oxazolidinone antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Enterococcus faecalisp |
| Resistomes with Sequence Variants | Enterococcus faecalisp |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + antibiotic target protection protein + antibiotic molecule + ABC-F ATP-binding cassette ribosomal protection protein + phenicol antibiotic [Drug Class] + oxazolidinone antibiotic [Drug Class] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic linezolid [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic florfenicol [Antibiotic] + confers_resistance_to_antibiotic tedizolid [Antibiotic] + Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins [AMR Gene Family] |
| Publications | Wang Y, et al. 2015. J. Antimicrob. Chemother. 70(8):2182-90 A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin. (PMID 25977397) |
Prevalence of optrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Enterococcus faecalis | 0% | 0.49% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 1300