Erm(47)

Accession ARO:3003908
CARD Short NameErm(47)
DefinitionChromosome-encoded gene conferring MLSB resistance. Identified from Helcococcus kunzii.
AMR Gene FamilyErm 23S ribosomal RNA methyltransferase
Drug Classstreptogramin antibiotic, lincosamide antibiotic, macrolide antibiotic, streptogramin B antibiotic
Resistance Mechanismantibiotic target alteration
Classification13 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic lincomycin [Antibiotic]
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
+ confers_resistance_to_antibiotic spiramycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ Erm 23S ribosomal RNA methyltransferase [AMR Gene Family]
+ confers_resistance_to_antibiotic quinupristin [Antibiotic]
Publications

Guérin F, et al. 2016. J. Antimicrob. Chemother. : Novel chromosome-encoded erm(47) determinant responsible for constitutive MLSB resistance in Helcococcus kunzii. (PMID 27494920)

Resistomes

Prevalence of Erm(47) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|ANZ79476.1|+|Erm(47) [Helcococcus kunzii]
MNRKSVRFGQNFVTSINDINKICKKIDVNSNDVYFEIGPGKGHFTQYFVERAKEVIAIEIDSELIPILNNKFSDLDNIKIINHDFMSYEL
PSTFKYKVFGNIPFNLSTSIIRKLSLEKYADEIYLIVELGFAKRLEDLNRKMGLMLAPFYEISILYNIPKRYFHPIPSVEVVLIKLKRTS
YNMSMKEYIKYEDFIEKWVKKDYNVLFTKNQLKQAIRYGNIDNLRILKVDQILSIFESYKLFNGLK


>gb|KU612222.1|+|80338-81078|Erm(47) [Helcococcus kunzii]
ATGAACAGAAAAAGTGTTAGATTTGGACAAAATTTTGTAACTTCTATTAATGATATAAACAAAATATGTAAGAAGATAGACGTGAATTCT
AATGATGTTTATTTTGAAATTGGTCCAGGTAAAGGGCATTTTACTCAATACTTTGTGGAAAGGGCTAAAGAGGTAATTGCTATTGAAATA
GACAGTGAATTAATTCCTATATTAAACAACAAATTTTCAGATCTAGATAATATAAAAATTATTAATCATGACTTTATGTCTTATGAATTA
CCATCTACATTTAAGTATAAAGTTTTTGGAAATATTCCATTTAATTTGAGTACTTCTATTATTCGTAAACTTAGTTTAGAAAAATATGCA
GATGAGATTTACTTAATAGTGGAATTAGGGTTTGCAAAAAGATTAGAAGACTTAAACCGTAAAATGGGACTAATGTTAGCTCCATTTTAT
GAAATTTCAATTTTATACAATATTCCAAAAAGATATTTTCATCCCATACCCAGTGTTGAGGTAGTGCTGATAAAACTAAAAAGAACTTCC
TATAATATGTCCATGAAAGAATATATAAAGTATGAAGACTTTATAGAAAAATGGGTAAAAAAGGATTATAATGTTTTATTTACAAAAAAT
CAGCTAAAACAAGCAATCAGATATGGAAATATTGATAATTTAAGAATCCTAAAAGTTGATCAAATTCTATCCATATTTGAAAGTTACAAA
TTATTTAATGGGTTAAAGTAA