msrC

Accession ARO:3002819
Synonym(s)msr(C)
CARD Short NamemsrC
DefinitionmsrC is a chromosomal-encoded ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to erythromycin and other macrolide and streptogramin B antibiotics.
AMR Gene Familymsr-type ABC-F protein
Drug Classstreptogramin antibiotic, streptogramin B antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesEnterococcus faeciumg+wgs
Resistomes with Sequence VariantsEnterococcus faeciumg+wgs
Classification10 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic quinupristin [Antibiotic]
+ msr-type ABC-F protein [AMR Gene Family]
Publications

Singh KV, et al. 2001. Antimicrob Agents Chemother 45(1): 263-266. Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility. (PMID 11120975)

Resistomes

Prevalence of msrC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Enterococcus faecium0.64%0%0.92%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 950


>gb|AAK01167.1|+|msrC [Enterococcus faecium]
MENLAVNITNLQVRFGNQLELSIDSLRVYQQDRIGIIGENGVGKTTLLKLIVGELIPNQGKIQTEITFNYLPQLTYLAEAKDLNLELASH
FQLKLEETSERKWSGGEERKIELIRLLSSYEQGMLLDEPTTHLDRKSMDRLIEELRYYYGTLIFVSHDRYFLDELATKVWEVKDGEIREF
PENYSAYLTQRELEKKTQLREAESIMKEKKRLEKSIQEKKKQAEKLEKVSSKKKKQQIRPDRLSSSKQKDSVQKAIQKNTKTLERRLQKI
GETTKPQQMKQIRFPVPKSLELHNRYPIMGQNIQLERSGRTLLINSDFQFSLGKKIAIVGENGSGKTTLLEHIRKQGEGILLSPKVSFQV
YQQKDYQMTSEESVIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCTLSGGEATRLTIALLFTKPSNVLLLDEPTNFIDVATIEALEQ
LMQVYPGTILFTSHDSYFVERTADEVYEIKGQKIKKVLTRNF


>gb|AF313494.1|+|1-1479|msrC [Enterococcus faecium]
ATGGAAAATTTAGCAGTAAATATAACAAACCTGCAAGTTCGTTTTGGTAACCAGTTAGAATTATCTATTGATTCTCTTCGTGTCTATCAG
CAAGATCGGATAGGAATCATAGGGGAAAATGGAGTCGGTAAAACAACGTTGCTGAAACTGATAGTCGGTGAACTTATCCCCAATCAAGGG
AAAATCCAAACAGAGATCACTTTCAACTATCTGCCTCAATTAACCTATCTTGCTGAGGCAAAGGACCTAAATTTGGAATTAGCCAGTCAT
TTCCAGTTGAAACTGGAAGAAACTTCGGAACGGAAATGGAGTGGAGGGGAAGAACGAAAGATCGAGTTGATACGTCTTCTTTCTTCTTAT
GAACAAGGGATGCTTCTAGACGAGCCGACAACCCATCTAGATAGAAAAAGTATGGATCGACTAATTGAAGAGCTTCGTTATTATTATGGC
ACGCTGATTTTTGTTAGTCATGACCGCTATTTTCTAGATGAGTTGGCAACGAAAGTCTGGGAAGTAAAAGACGGAGAAATCCGAGAGTTT
CCGGAGAATTATAGTGCCTATCTCACTCAAAGGGAATTGGAGAAAAAGACTCAGCTACGAGAAGCAGAGTCGATCATGAAAGAGAAAAAA
CGATTGGAAAAATCGATCCAAGAAAAGAAAAAACAAGCGGAAAAGTTAGAAAAAGTGTCCAGTAAAAAGAAAAAGCAACAAATCAGACCG
GATCGGTTGTCTTCCTCTAAACAAAAAGACAGTGTACAAAAAGCCATCCAAAAGAATACGAAAACATTAGAGAGAAGACTCCAAAAAATA
GGAGAAACAACCAAACCGCAACAGATGAAACAAATCCGTTTTCCAGTACCAAAATCTCTTGAACTCCACAATCGTTATCCAATCATGGGA
CAAAATATCCAATTGGAAAGAAGCGGAAGAACATTACTGATAAATAGCGATTTTCAATTTTCTTTAGGTAAAAAAATCGCGATTGTCGGC
GAAAATGGATCAGGTAAGACAACTTTATTGGAACATATCCGCAAACAAGGAGAAGGAATCCTTCTCTCTCCGAAAGTAAGCTTTCAAGTA
TATCAGCAAAAGGATTATCAAATGACATCTGAAGAATCCGTCATTCGTTTTGTCATGAGACAAACAGAGTTTTCGGAATCACTTGTCCGC
AGTTTGTTGAATCATTTAGGGTTTGCTCAGGAAACTCTGACGAAACCGTTGTGTACGTTAAGTGGGGGAGAAGCGACTCGTTTGACGATT
GCTTTGCTTTTTACTAAGCCAAGTAATGTGTTGCTGTTAGATGAACCGACTAATTTCATTGATGTGGCAACGATCGAAGCTTTAGAGCAG
CTGATGCAAGTATATCCGGGAACGATTTTGTTTACTTCACATGATTCCTACTTTGTCGAGCGTACGGCTGATGAAGTTTATGAAATAAAA
GGGCAGAAAATAAAAAAAGTACTTACGAGAAATTTTTAA