| Accession | ARO:3000251 |
| Synonym(s) | msr(A) |
| CARD Short Name | msrA |
| Definition | MsrA is an ABC-F subfamily ribosomal protection protein expressed in Staphylococcus species which confers resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. It is associated with plasmid DNA. |
| AMR Gene Family | msr-type ABC-F protein |
| Drug Class | streptogramin antibiotic, macrolide antibiotic, streptogramin B antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Sequence Variants | Listeria monocytogeneswgs, Mycobacterium aviumwgs, Providencia alcalifacienswgs, Staphylococcus arlettaeg+wgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus equorump+wgs, Staphylococcus haemolyticusg+p+wgs+gi, Staphylococcus hominisp+wgs, Staphylococcus massiliensiswgs, Staphylococcus pasteuriwgs, Staphylococcus saprophyticusp+wgs, Staphylococcus warnerip+wgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + streptogramin antibiotic [Drug Class] + antibiotic target protection protein + macrolide antibiotic [Drug Class] + ABC-F ATP-binding cassette ribosomal protection protein + streptogramin B antibiotic [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic quinupristin [Antibiotic] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + msr-type ABC-F protein [AMR Gene Family] |
| Publications | Poole K. 2005. J Antimicrob Chemother 56(1): 20-51. Efflux-mediated antimicrobial resistance. (PMID 15914491) |
Prevalence of msrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Listeria monocytogenes | 0% | 0% | 0.02% | 0% |
| Mycobacterium avium | 0% | 0% | 0.48% | 0% |
| Providencia alcalifaciens | 0% | 0% | 3.45% | 0% |
| Staphylococcus arlettae | 100% | 0% | 65% | 0% |
| Staphylococcus aureus | 2.62% | 3.31% | 8.62% | 0.86% |
| Staphylococcus capitis | 10% | 0% | 3.16% | 0% |
| Staphylococcus epidermidis | 5.16% | 3.75% | 21% | 0% |
| Staphylococcus equorum | 0% | 5.41% | 12.5% | 0% |
| Staphylococcus haemolyticus | 31.03% | 3.77% | 32.31% | 13.33% |
| Staphylococcus hominis | 0% | 10.42% | 20.98% | 0% |
| Staphylococcus massiliensis | 0% | 0% | 14.29% | 0% |
| Staphylococcus pasteuri | 0% | 0% | 15.38% | 0% |
| Staphylococcus saprophyticus | 0% | 5.41% | 13.99% | 0% |
| Staphylococcus warneri | 0% | 10% | 14.75% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 800