erm(55)

Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3009647
CARD Short Nameerm(55)
Definitionerm(55) is a plasmid-borne 23S rRNA methyltransferase identified from Mycobacterium chelonae.
AMR Gene FamilyErm-like 23S rRNA methyltransferase
Drug Classstreptogramin antibiotic, lincosamide antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target alteration
Classification13 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic clarithromycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ Erm-like 23S rRNA methyltransferase [AMR Gene Family]
Publications

Alexander DC, et al. 2025. Microbiol Spectr 13(3):e0239724 Macrolide resistance due to erm(55). (PMID 39817789)

Resistomes

Prevalence of erm(55) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|WHP53453.1|+|erm(55) [Mycobacteroides chelonae]
MPTFRAGRHEFGQNFLTDQPTIDHIVKLVSQSNGPIIEIGSGAGALTLPMQTLLRPITAVEIDPRQVQALRRQVNSRTTVVHDDFLHFRL
PRSPHTIVGNLPFHQTTAMLRRILHSDHWTTAVLLVQWEVARRRAAVGGATMMTAQSWPWYTFQLVGRIPAAAFTPRPGVDAGLMTITRR
TVPLVNTAQRKQYSAFVHAVFTSKGSGLRQILPRVADASAKGGVMTWITQQRLSNSSLPRDLTPEQWAEIFAIATRHAAAATPKRSRNGR


>gb|OQ656455.1|+|320-1132|erm(55) [Mycobacteroides chelonae]
ATGCCTACTTTCCGTGCTGGCCGCCACGAATTCGGCCAGAACTTCTTGACTGACCAACCGACGATCGACCACATTGTCAAACTCGTCTCG
CAAAGCAACGGTCCGATCATCGAAATTGGTTCCGGCGCAGGGGCATTGACGCTTCCAATGCAAACCCTGCTACGGCCTATCACGGCCGTC
GAGATAGACCCGCGACAGGTCCAAGCGCTCCGACGCCAGGTGAACTCGCGAACAACCGTTGTGCATGATGACTTCCTACACTTTCGACTA
CCGCGATCGCCGCACACCATCGTGGGAAACTTGCCATTCCACCAGACCACCGCGATGCTTCGGCGCATCCTGCACTCCGACCACTGGACG
ACCGCAGTCCTGCTCGTGCAGTGGGAGGTCGCGCGCCGCCGCGCAGCAGTGGGAGGCGCGACTATGATGACGGCGCAAAGCTGGCCGTGG
TATACGTTCCAACTGGTTGGCCGCATTCCAGCAGCGGCATTCACACCCCGGCCGGGAGTCGATGCCGGCCTGATGACCATCACCCGGCGC
ACCGTCCCCCTCGTGAACACCGCCCAGCGCAAGCAATACAGCGCGTTCGTCCACGCCGTCTTCACAAGCAAAGGCAGCGGTCTGCGTCAG
ATTCTGCCGCGCGTCGCCGACGCCTCGGCGAAAGGTGGGGTCATGACATGGATTACACAGCAGCGACTCTCAAATTCATCTCTGCCTCGT
GATCTCACGCCAGAGCAGTGGGCCGAGATCTTCGCCATCGCCACTCGACACGCTGCAGCAGCCACTCCCAAACGTTCGAGGAACGGGCGA
TGA

Curator Acknowledgements
Curator Description Most Recent Edit