thiostrepton [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000686
Synonym(s)bryamycin thiactin
DefinitionThiostrepton is a cyclic peptide active against Gram-positive bacteria. It is produced by streptomyces bacteria.
SMILESC=C(NC(=O)C(=C)NC(=O)c1csc(C2=N[C@@H]3c4csc(n4)[C@H]4NC(=O)c5csc(n5)[C@H]([C@](C)(O)[C@@H](C)O)NC(=O)[C@H]5CSC(=N5)/C(=C/C)NC(=O)[C@H]([C@@H](C)O)NC(=O)c5csc(n5)[C@]3(CC2)NC(=O)[C@H](C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)N[C@@H]2C=Cc3c([C@H](C)O)cc(nc3[C@H]2O)C(=O)O[C@@H]4C)n1)C(N)=O
PubChem16129666
ChEBI29693
CAS1393-48-2
ChEMBLCHEMBL1236460
Drug Classpeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ peptide antibiotic [Drug Class]
Sub-Term(s)
2 ontology terms | Show
+ 50S ribosomal subunit P-site targeted_by_antibiotic
+ tsnR confers_resistance_to_antibiotic
Publications

Anderson B, et al. 1970. Nature 225(5229): 233-235. The structure of thiostrepton. (PMID 5409975)

Curator Acknowledgements
Curator Description Most Recent Edit