srmB

Accession ARO:3002828
DefinitionsrmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin
AMR Gene FamilyABC-F ATP-binding cassette ribosomal protection protein
Drug Classstreptogramin antibiotic, pleuromutilin antibiotic, phenicol antibiotic, oxazolidinone antibiotic, tetracycline antibiotic, macrolide antibiotic, lincosamide antibiotic
Resistance Mechanismantibiotic target protection
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ ABC-F ATP-binding cassette ribosomal protection protein [AMR Gene Family]
Publications

Schoner B, et al. 1992. Gene 115(1-2): 93-96. Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins. (PMID 1612454)

Resistomes

Prevalence of srmB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1050


>gb|CAA45050.1|+|srmB [Streptomyces ambofaciens]
MSIAQYALHDITKRYHDCVVLDRVGFSIKPGEKVGVIGDNGSGKSTLLKILAGRVEPDNGALTVVAPGGVGYLAQTLELPLDATVQDAVD
LALSDLRELEAAMREAEAELGESDENGSERELSAGLQRYAALVEQYQARGGYEADVRVEVALHGLGLPSLDRDRKLGTLSGGERSRLALA
ATLASSPELLLLDEPTNDLDDRAMEWLEDHLAGHRGTVIAVTHDRVFLDRLTTTILEVDSGSVTRYGNGYEGYLTAKAVERERRLREYEE
WRAELDRNRGLITSNVARMDGIPRKMSLSVFGHGAYRRRGRDHGAMVRIRNAKQRVAQLTENPVHAPADPLSFAARIDTAGPEAEEAVAE
LTDVRVAGRLAVDSLTIRPGERLLVTGPNGAGKSTLLRVLSGELEPDGGSVRVGCRVGHLRQDETPWAPGLTVLRAFAQGREGYLEDHAE
KLLSLGLFSPSDLRRRVKDLSYGQRRRIEIARLVSDPMDLLLLDEPTNHLTPVLVEELEQALADYRGAVVVVTHDRRMRSRFTGARLTMG
DGRIAEFSAG


>gb|X63451|+|1-1653|srmB [Streptomyces ambofaciens]
GTGTCGATTGCGCAATACGCCCTACACGACATCACGAAGCGCTACCACGACTGTGTCGTGCTCGACCGGGTCGGTTTCAGCATCAAGCCG
GGCGAGAAGGTCGGCGTGATCGGCGACAACGGTTCCGGCAAGTCCACGCTGCTCAAGATCCTCGCCGGCCGCGTGGAGCCCGACAACGGC
GCGCTCACCGTGGTCGCTCCCGGCGGCGTCGGCTACCTGGCGCAGACACTGGAACTGCCCCTCGACGCCACCGTCCAGGACGCCGTCGAC
CTGGCCCTGTCCGACCTGCGCGAGCTCGAAGCGGCGATGCGCGAGGCCGAGGCGGAGCTGGGCGAGAGCGACGAGAACGGCTCCGAGCGC
GAGCTGTCCGCCGGCCTCCAGCGCTACGCCGCTCTGGTCGAGCAGTACCAGGCGCGTGGCGGCTACGAGGCCGACGTGCGCGTGGAGGTC
GCGCTGCACGGCCTCGGACTGCCGAGCCTGGACCGCGACCGCAAGCTCGGAACCCTCTCCGGTGGCGAACGCTCCCGCCTCGCGCTCGCC
GCGACCCTCGCCTCGTCGCCGGAGCTGCTGCTCCTGGACGAACCGACCAACGACCTCGACGACCGGGCGATGGAATGGCTGGAGGACCAC
CTGGCCGGCCACCGCGGCACGGTGATCGCGGTCACCCACGACCGGGTCTTCCTCGACCGGCTCACCACCACGATCCTGGAGGTCGACTCC
GGCAGCGTCACCCGCTACGGCAACGGCTACGAGGGCTACCTGACGGCCAAGGCCGTGGAACGCGAGCGGCGGCTGCGGGAGTACGAGGAG
TGGCGTGCCGAACTCGACCGCAACCGCGGGCTGATCACCTCCAACGTGGCGCGGATGGACGGCATCCCGCGCAAGATGTCCCTCTCCGTG
TTCGGCCACGGCGCCTACCGCAGGCGAGGGCGCGACCACGGCGCGATGGTGCGGATCCGCAACGCGAAGCAACGCGTGGCGCAGCTGACC
GAGAACCCGGTCCACGCTCCCGCCGACCCGTTGTCCTTCGCCGCCCGCATCGACACCGCGGGCCCGGAGGCGGAGGAGGCGGTGGCCGAA
CTCACCGACGTGCGCGTCGCGGGTCGGCTCGCCGTGGACTCCCTGACGATCCGGCCCGGCGAACGGCTGCTCGTCACAGGTCCCAACGGT
GCGGGCAAGTCCACCTTGTTGCGGGTGCTGTCCGGGGAACTGGAGCCGGACGGCGGCTCGGTGCGCGTCGGCTGCCGGGTCGGTCATCTG
CGGCAGGACGAGACGCCCTGGGCGCCCGGACTGACCGTGCTGCGGGCCTTCGCCCAGGGCCGGGAGGGCTACCTGGAGGACCACGCGGAG
AAACTGCTGTCGCTCGGCCTGTTCAGCCCGTCCGACCTGCGGCGACGCGTGAAGGATCTGTCCTACGGGCAGCGCCGCCGGATCGAGATC
GCCCGGCTGGTGAGCGACCCGATGGACCTGCTGCTGCTGGACGAGCCCACCAACCACCTCACCCCGGTGCTGGTGGAGGAGTTGGAGCAG
GCACTCGCGGACTACCGCGGCGCCGTCGTGGTCGTCACCCACGACCGTCGGATGCGGTCCCGGTTCACCGGCGCCCGGCTGACCATGGGA
GACGGGCGCATCGCCGAGTTCAGCGCCGGCTGA