LpeA

Accession ARO:3004099
Synonym(s)lpp2879
DefinitionLpeA is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrA in E. coli.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesLegionella pneumophilag+wgs
Classification11 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Massip C, et al. 2017. J. Antimicrob. Chemother. : Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. (PMID 28137939)

Resistomes

Prevalence of LpeA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Legionella pneumophila4.3%0%14.17%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 680


>gb|CAH14032.1|+|LpeA [Legionella pneumophila str. Paris]
MLGIQFNRGQWRSNYYWQIPVLIIAVISILFFISKKLFYSKVTPESIPNKLVEVEPIKSHNLQQTIHLLGTIHPKHATTLIAKESGMLDT
LIPTGQKVTKGTLIAKINNPDLEKNLQLSLSAVELAKAQYERITPLIKSGYVSTKEVEEKKQAWIDAQKELSKTRIELDNLRFYAPFDGI
IGAYKKREGAQVNAGESVVSIYDPSALVVDFDIPCSNLATLNEGQPVYVLGKRYSLSHLQKMLDEDTHMCPADVDIQCDDCLIGATTSVE
LLVAEKNNTIVIPFQAIFLRNSKPFVYLVKKGKIVLASVKTGLQQEDKIEIVEGLKAGQQLVTKGQERLYPEMTVDIYHPATSSS


>gb|CR628336.1|+|3280794-3281861|LpeA [Legionella pneumophila str. Paris]
GTGTTAGGAATTCAATTCAATAGAGGTCAATGGCGGTCAAACTATTATTGGCAAATACCTGTGCTGATAATAGCTGTTATTAGCATTCTG
TTTTTCATCAGTAAAAAATTATTCTACTCAAAAGTTACGCCAGAAAGCATACCTAATAAACTGGTGGAAGTTGAGCCCATTAAAAGCCAC
AACTTACAACAAACAATCCATTTATTAGGTACCATTCATCCAAAACACGCAACGACATTAATTGCTAAAGAATCAGGTATGTTGGACACC
CTTATCCCAACTGGTCAAAAAGTCACAAAAGGGACACTTATTGCAAAAATCAACAACCCTGATCTTGAAAAAAATCTACAGCTTTCATTA
AGTGCGGTAGAATTGGCAAAAGCACAATATGAACGTATCACCCCTTTAATTAAATCAGGATATGTCAGTACAAAGGAAGTCGAAGAAAAA
AAACAAGCCTGGATTGATGCCCAAAAAGAATTATCAAAAACAAGGATTGAATTAGATAACCTCCGCTTTTACGCTCCTTTCGACGGAATA
ATTGGAGCATACAAAAAGAGAGAAGGAGCACAAGTCAATGCAGGTGAATCTGTTGTAAGTATTTACGACCCTTCTGCTTTAGTTGTCGAT
TTTGATATTCCTTGCAGTAATTTGGCAACTCTTAATGAAGGTCAGCCGGTTTATGTGCTGGGTAAACGGTATTCATTAAGTCATTTACAA
AAAATGCTCGACGAAGACACCCACATGTGCCCTGCTGATGTTGATATTCAATGTGATGATTGTCTTATTGGTGCGACCACAAGTGTTGAG
CTCCTTGTTGCGGAAAAAAATAACACTATTGTCATCCCCTTCCAGGCAATATTTTTGAGAAATAGTAAACCTTTTGTATATCTTGTAAAA
AAGGGAAAGATTGTGCTTGCTTCAGTGAAAACTGGGTTGCAACAAGAGGATAAAATTGAAATTGTCGAGGGATTAAAAGCTGGGCAACAA
CTGGTTACAAAAGGCCAGGAACGCTTATATCCTGAAATGACCGTTGATATTTATCATCCAGCGACAAGTAGCAGCTAA