Accession ARO:3000771
DefinitionAdeFGH is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It confers resistance to fluoroquinolone, tetracycline, tigecycline, chloramphenicol, clindamycin, trimethoprim, and sulfamethoxazole.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
4 ontology terms | Show
+ adeF part_of
+ adeG part_of
+ adeH part_of
+ adeL regulates

Cortez-Cordova J and Kumar A. 2011. Int J Antimicrob Agents 37(5): 420-424. Activity of the efflux pump inhibitor phenylalanine-arginine beta-naphthylamide against the AdeFGH pump of Acinetobacter baumannii. (PMID 21377839)

Coyne S, et al. 2010. Antimicrob Agents Chemother 54(10): 4389-4393. Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. (PMID 20696879)