adeH

Accession ARO:3000779
CARD Short NameadeH
DefinitionAdeH is the outer membrane channel protein of the AdeFGH multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Sequence VariantsAcinetobacter baumanniig+p+wgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Coyne S, et al. 2010. Antimicrob Agents Chemother 54(10): 4389-4393. Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. (PMID 20696879)

Resistomes

Prevalence of adeH among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii72.39%0.05%50.09%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 900


>gb|CAJ77855.1|+|adeH [Acinetobacter baumannii AYE]
MVITSKQNWLLSSLMGSLLLAGCSLAPEYQPAKVIVPVKFKESDPKLEDNNWKIAQPADQQTRGEWWRIYNDAQLNELEQQAIAGNQNLK
AVAANIQASRALRSAAQAERLPSIDAGFGPTRQKPSPASLGLDDNAHTSAQTLWRAQANVSYELDLFGRVASSVNAATADLQQQEALYQS
ALLALQADVAQGYFLIRQLDTEQAIYNRTIKLLGETRDLMQLRFKNGLVSELDVSRAQTELATAQTTALNIARNRASAEHALAVLLGKPP
ADFNLAVQPLTANSIRLPAGLPSTLLERRPDIAAAERAMAADNARIGIARAAFFPKLSLTGALGYESSSLSELGKWSSRTFLLGPVAGTI
LSLPLFDGGQRKAGVAQARAAYEESVANYRQTVLNAFREVENGLSDQRILDQQIQAQNQALSSSRHANQLSHLRYREGAISYLDVIDSDR
TILQQEQLAAQLKGSQIIASINLIRALGGGWSS


>gb|CT025802.2|+|1-1452|adeH [Acinetobacter baumannii AYE]
TTGGTGATTACATCAAAACAAAACTGGTTGTTGTCCTCACTCATGGGAAGCCTGCTCCTTGCAGGCTGCTCATTGGCCCCAGAATATCAA
CCTGCAAAAGTTATAGTGCCAGTCAAATTCAAAGAATCTGACCCCAAACTTGAAGATAATAACTGGAAGATTGCCCAACCTGCTGATCAG
CAAACTCGTGGTGAATGGTGGCGCATTTACAATGATGCTCAACTGAATGAACTTGAACAGCAAGCTATCGCGGGCAACCAGAACCTAAAA
GCGGTGGCAGCAAATATTCAGGCTTCACGTGCATTACGTTCGGCAGCTCAAGCTGAACGCTTACCAAGTATTGATGCCGGATTTGGGCCA
ACCCGCCAAAAGCCGTCTCCGGCTTCACTCGGTTTAGATGACAATGCACATACTTCGGCTCAAACCTTATGGCGAGCTCAAGCCAATGTT
TCATATGAGCTCGATTTATTTGGTCGTGTAGCAAGTAGTGTCAACGCAGCAACAGCGGATCTACAGCAACAAGAGGCACTATATCAGTCG
GCACTTTTAGCTCTACAAGCGGATGTAGCTCAAGGTTATTTTCTGATACGTCAACTTGATACCGAACAGGCAATTTATAACCGTACAATC
AAATTATTAGGTGAAACACGAGATTTAATGCAGCTTCGTTTTAAAAACGGACTGGTCAGTGAATTAGATGTTTCTCGTGCACAAACCGAA
CTTGCTACCGCACAAACCACTGCCCTAAATATTGCTCGTAACAGAGCCAGTGCAGAACATGCGCTTGCAGTCTTATTAGGAAAACCACCA
GCAGACTTTAACTTGGCAGTTCAACCTTTAACTGCAAATAGTATCCGTCTCCCTGCCGGTTTGCCGTCAACTTTACTTGAAAGACGACCC
GATATTGCGGCTGCAGAGCGTGCAATGGCAGCAGATAATGCGCGTATTGGAATTGCTCGTGCAGCATTTTTCCCAAAACTCAGTCTTACA
GGAGCTTTAGGTTATGAATCTTCAAGTTTAAGCGAGTTGGGTAAATGGTCGAGTCGGACTTTTTTACTAGGACCTGTCGCTGGTACTATT
TTGTCGTTACCTTTATTTGATGGTGGACAACGTAAAGCAGGCGTTGCTCAAGCAAGAGCGGCTTATGAGGAAAGCGTCGCCAACTATAGA
CAAACTGTACTGAATGCATTTCGCGAAGTTGAAAATGGTTTATCTGATCAAAGAATTCTCGATCAGCAAATTCAGGCTCAAAACCAAGCA
CTCTCCTCTTCTCGTCATGCCAATCAACTTTCTCATTTACGTTATCGAGAAGGTGCTATTAGCTATCTTGATGTCATTGATTCTGACCGC
ACTATTTTGCAACAAGAACAATTAGCAGCTCAGCTGAAAGGCAGCCAAATCATTGCAAGCATCAATTTAATCCGTGCTTTAGGGGGCGGT
TGGAGTAGTTAA