adeG

Accession ARO:3000778
DefinitionAdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesAcinetobacter baumanniig+wgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Cortez-Cordova J and Kumar A. 2011. Int J Antimicrob Agents 37(5): 420-424. Activity of the efflux pump inhibitor phenylalanine-arginine beta-naphthylamide against the AdeFGH pump of Acinetobacter baumannii. (PMID 21377839)

Resistomes

Prevalence of adeG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii99.36%0%99.65%
Acinetobacter nosocomialis100%0%100%
Klebsiella pneumoniae0%0%0%
Salmonella enterica0%0%0.03%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 800


>gb|CAJ77857.1|+|adeG [Acinetobacter baumannii AYE]
MSFSRKQFALSAIFVAILATGGSFMLLHENADAKAAPTAAQQAATVDVAPVVSKTITDWQEYSGRLEAIDQVDIRPQVSGKLIAVHFKDG
SLVKKGDLLFTIDPRPFEAELNRAKAQLASAEAQVTYTASNLSRIQRLIQSNAVSRQELDLAENDARSANANLQAARAAVQSARLNLEYT
RITAPVSGRISRAEVTVGNVVSAGNGAQVLTSLVSVSRLYASFDVDEQTYLKYISNQRNSAQVPVYMGLANETGFTREGTINSIDNNLNT
TSGTIRVRATFDNPNGVLLPGLYARIRLGGGQPRPAILISPTAVGVDQDKRFVVVVDAKNQTAYREVKLGAQQDGLQIVNSGLQAGDRIV
VNGLQRIRPGDPVTPHLVPMPNSQITASATPPQPQPTDKTSTPAKG


>gb|CT025800.2|+|1-1221|adeG [Acinetobacter baumannii AYE]
ATGTCATTTTCCCGCAAACAGTTTGCACTGTCTGCCATCTTTGTCGCTATTTTAGCAACCGGTGGCAGTTTTATGTTGTTACATGAAAAT
GCCGATGCAAAAGCTGCACCAACCGCTGCCCAACAAGCTGCTACTGTTGATGTAGCCCCAGTAGTAAGCAAAACCATTACCGATTGGCAA
GAATATTCCGGTCGTTTAGAAGCAATTGATCAAGTTGATATTCGGCCTCAAGTTTCAGGAAAACTTATTGCCGTACATTTCAAAGATGGA
AGCCTCGTTAAAAAAGGTGATTTACTTTTCACAATCGACCCTCGTCCTTTTGAAGCAGAACTGAACCGTGCAAAAGCCCAACTTGCTTCA
GCTGAAGCACAGGTAACATATACCGCAAGCAATCTTTCGCGTATTCAACGTCTCATTCAGAGTAATGCTGTTTCTCGCCAAGAACTGGAT
TTAGCCGAAAATGATGCACGTTCAGCGAATGCTAACCTACAAGCCGCTAGAGCTGCTGTCCAATCTGCACGTTTAAATCTAGAATACACC
CGTATTACAGCACCTGTCAGCGGCCGGATTTCACGAGCTGAAGTCACCGTTGGTAATGTAGTTTCTGCAGGTAACGGCGCACAGGTTTTA
ACAAGTTTAGTGTCTGTATCCCGCCTTTATGCATCTTTCGATGTTGATGAACAAACTTACCTGAAATATATCAGTAATCAGCGTAATTCA
GCACAAGTACCTGTCTATATGGGACTTGCCAATGAAACAGGCTTTACTCGTGAAGGTACAATCAACTCAATCGATAACAATCTGAATACA
ACCTCAGGTACGATCCGTGTTCGCGCAACTTTTGACAATCCAAACGGTGTTTTATTACCAGGCCTATATGCACGAATTCGTTTAGGTGGA
GGCCAACCTCGCCCAGCGATTCTGATTAGTCCAACCGCGGTTGGTGTCGACCAAGATAAACGTTTTGTCGTAGTAGTAGATGCGAAAAAT
CAAACTGCTTATCGCGAAGTAAAACTCGGTGCCCAACAAGATGGCTTGCAAATCGTAAATAGCGGATTACAAGCGGGTGATCGTATTGTA
GTGAATGGTTTACAACGGATTCGTCCGGGTGACCCTGTTACACCGCATCTCGTCCCTATGCCAAATTCACAAATCACTGCTAGCGCTACT
CCTCCTCAACCTCAGCCAACAGATAAAACATCAACTCCGGCAAAAGGTTAA