MtrCDE

Accession ARO:3000369
DefinitionThe mtr (multiple transferable resistance) system of Neisseria gonorrhoeae confers resistance to many hydrophobic agents including antibiotics, fatty-acids and detergents. MtrCDE is homologous to AcrAB-TolC, where MtrC is the membrane fusion protein, MtrD is the inner membrane transporter, and MtrE is the outer membrane channel protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpenam, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification9 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic penicillin [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
Sub-Term(s)
5 ontology terms | Show
+ mtrC part_of
+ mtrD part_of
+ mtrE part_of
+ mtrA regulates
+ mtrR regulates
Publications

Hagman KE, et al. 1995. Microbiology 141(PT 3): 611-622. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. (PMID 7711899)

Jerse AE, et al. 2003. Infect Immun 71(10): 5576-5582. A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection. (PMID 14500476)