mtrE

Accession ARO:3000812
DefinitionMtrE is an outer membrane exporter protein that is part of the MtrCDE multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, glycylcycline, phenicol antibiotic, monobactam, macrolide antibiotic, antibacterial free fatty acids, triclosan, acridine dye, diaminopyrimidine antibiotic, penam, carbapenem, aminoglycoside antibiotic, fluoroquinolone antibiotic, aminocoumarin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification26 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Jerse AE, et al. 2003. Infect Immun 71(10): 5576-5582. A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection. (PMID 14500476)

Resistomes

Prevalence of mtrE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Neisseria gonorrhoeae94.87%0%87.11%
Neisseria meningitidis0%0%0.34%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 910


>gb|CAA64891.1|+|mtrE [Neisseria gonorrhoeae]
MNTTLKTTLTSVAAAFALSACTMIPQYEQPKVEVAETFQNDTSVSSIRAVDLGWHDYFADPRLQKLIDIALERNTSLRTAVLNSEIYRKQ
YMIERNNLLPTLAANANGSRQGSLSGGNVSSSYNVGLGAASYELDLFGRVRSSSEAALQGYFASVANRDAAHLSLIATVAKAYFNERYAE
EAMSLAQRVLKTREETYNAVRIAVQGRRDFRRRPAPAEALIESAKADYAHAARSREQARNALATLINRPIPEDLPAGLPLDKQFFVEKLP
AGLSSEVLLDRPDIRAAEHALKQANANIGAARAAFFPSIRLTGSVGTGSVELGGLFKSGTGVWAFAPSITLPIFTWGTNKANLDVAKLRQ
QAQIVAYESAVQSAFQDVANALAAREQLDKAYDALSKQSRASKEALRLVGLRYKHGVSGALDLLDAERSSYSAEGAALSAQLTRAENLAD
LYKALGGGLKRDTQTGK


>gb|X95635|+|260-1663|mtrE [Neisseria gonorrhoeae]
ATGAATACTACATTGAAAACTACCTTGACCTCTGTTGCAGCAGCCTTTGCATTGTCTGCCTGCACCATGATTCCTCAATACGAGCAGCCC
AAAGTCGAAGTTGCGGAAACCTTCCAAAACGACACATCGGTTTCTTCCATCCGCGCGGTTGATTTGGGTTGGCATGACTATTTTGCCGAC
CCGCGCCTGCAAAAGCTGATCGACATCGCACTCGAGCGCAATACCAGTTTGCGTACAGCCGTATTGAACAGCGAAATCTACCGCAAACAA
TACATGATCGAGCGCAACAACCTCCTGCCCACGCTTGCCGCCAATGCGAACGGCTCGCGCCAAGGCAGCTTGAGCGGCGGCAATGTCAGC
AGCAGCTACAATGTCGGACTGGGTGCGGCATCTTACGAACTCGATCTGTTCGGGCGCGTGCGCAGCAGCAGCGAAGCAGCACTGCAAGGC
TATTTTGCCAGCGTTGCCAACCGCGATGCGGCACATTTGAGTCTGATTGCCACCGTTGCCAAAGCCTATTTCAACGAGCGTTATGCCGAA
GAAGCGATGTCTTTGGCGCAGCGTGTCTTGAAAACGCGCGAGGAAACCTACAATGCTGTCCGAATTGCGGTACAAGGCAGGCGTGATTTC
CGCCGTCGCCCTGCGCCAGCAGAAGCCTTGATTGAATCTGCCAAAGCCGATTATGCCCATGCCGCGCGCAGCCGCGAACAGGCGCGCAAT
GCCTTGGCAACCTTGATTAACCGTCCGATACCCGAAGACCTGCCCGCCGGTTTGCCGTTGGACAAGCAGTTTTTTGTTGAAAAACTGCCT
GCCGGTTTGAGTTCCGAAGTATTGCTCGACCGTCCCGACATCCGCGCCGCCGAACACGCGCTCAAACAGGCAAACGCCAATATCGGTGCG
GCGCGCGCCGCCTTTTTCCCGTCCATCCGCCTGACCGGAAGCGTCGGTACGGGTTCTGTCGAATTGGGCGGGCTGTTCAAAAGCGGCACG
GGCGTTTGGGCGTTCGCGCCGTCTATTACCCTGCCGATTTTTACTTGGGGAACGAACAAGGCGAACCTTGATGTGGCAAAACTGCGCCAA
CAGGCACAAATTGTTGCCTATGAATCCGCCGTCCAATCCGCCTTTCAAGACGTGGCAAACGCATTGGCGGCGCGCGAGCAGCTGGATAAA
GCCTATGACGCTTTAAGCAAACAAAGCCGCGCCTCTAAAGAAGCGTTGCGCTTGGTCGGACTGCGTTACAAACACGGCGTATCCGGCGCG
CTCGATTTGCTCGATGCGGAACGCAGCAGCTATTCGGCGGAAGGTGCGGCTTTGTCGGCACAACTGACCCGCGCCGAAAACCTTGCCGAT
TTGTACAAGGCGCTCGGCGGCGGATTGAAACGGGATACCCAAACCGGCAAATAA