mtrC

Accession ARO:3000810
DefinitionMtrC is the membrane fusion protein of the MtrCDE multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classmacrolide antibiotic, penam
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesNeisseria meningitidisg+wgs
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Jerse AE, et al. 2003. Infect Immun 71(10): 5576-5582. A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection. (PMID 14500476)

Resistomes

Prevalence of mtrC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Neisseria gonorrhoeae94.87%0%87.29%
Neisseria meningitidis100%0%96.66%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 790


>gb|AAF42063.1|-|mtrC [Neisseria meningitidis MC58]
MAFYAFKAMRAAALAAAVALVLSSCGKGGDAAQGGQPAGREAPAPVVGVVTVHPQTVALTVELPGRLESLRTADVRAQVGGIIQKRLFQE
GSYVRAGQPLYQIDSSTYEAGLESARAQLATAQATLAKADADLARYKPLVAAEAVSRQEYDAAVTAKRSAEAGVKAAQAAIKSAGISLNR
SRITAPISGFIGQSKVSEGTLLNAGDATVLATIRQTNPMYVNVTQSASEVMKLRRQIAEGKLLAADGVIAVGIKFDDGTVYPEKGRLLFA
DPAVNESTGQITLRAAVPNDQNILMPGLYVRVLMDQVAVDNAFVVPQQAVTRGAKDTVMIVNAQGGMEPREVTVAQQQGTNWIVTSGLKD
GDKVVVEGISIAGITGAKKVTPKEWASSENQAAAPQSGVQTASEAKPASEAK


>gb|AE002098.2|-|1795182-1796420|mtrC [Neisseria meningitidis MC58]
ATGGCTTTTTATGCTTTTAAGGCGATGCGTGCGGCCGCGTTGGCTGCCGCCGTTGCATTGGTACTGTCGTCTTGCGGTAAAGGCGGAGAC
GCGGCGCAGGGCGGGCAGCCTGCTGGTCGGGAAGCCCCTGCGCCCGTCGTCGGTGTCGTAACCGTCCATCCGCAAACCGTCGCATTGACC
GTCGAGTTGCCGGGGCGTTTGGAATCGCTGCGTACCGCCGATGTCCGCGCCCAAGTCGGCGGCATCATCCAAAAACGCCTGTTCCAAGAA
GGCAGTTATGTCCGTGCCGGACAGCCGCTGTATCAGATCGACAGTTCCACTTATGAAGCAGGTCTGGAAAGCGCGCGCGCGCAACTGGCA
ACGGCTCAGGCAACGCTTGCCAAAGCGGATGCGGATTTGGCGCGATACAAGCCTTTGGTTGCCGCCGAAGCCGTCAGCCGGCAGGAATAC
GATGCTGCGGTAACGGCGAAACGTTCTGCCGAGGCAGGCGTTAAAGCGGCGCAGGCGGCAATCAAATCCGCCGGCATCAGCCTGAACCGT
TCGCGCATTACCGCGCCGATTTCCGGCTTTATCGGTCAGTCCAAAGTTTCCGAAGGTACGTTGCTGAACGCTGGCGATGCGACCGTACTG
GCGACCATCCGCCAAACCAATCCGATGTATGTGAACGTTACCCAGTCTGCATCCGAAGTGATGAAATTGCGCCGTCAGATAGCCGAAGGC
AAACTGCTGGCGGCGGATGGTGTGATTGCGGTCGGCATCAAATTTGACGACGGCACAGTTTACCCTGAAAAAGGCCGCCTGCTGTTTGCC
GATCCGGCCGTCAACGAATCGACCGGTCAGATTACCCTGCGCGCCGCCGTACCGAACGATCAGAATATCTTGATGCCCGGTCTGTATGTG
CGCGTGCTGATGGACCAAGTGGCGGTGGATAACGCATTTGTTGTGCCGCAGCAGGCGGTAACGCGCGGTGCGAAAGATACCGTGATGATT
GTGAATGCCCAAGGCGGTATGGAACCCCGCGAGGTAACGGTTGCGCAACAGCAGGGTACGAATTGGATTGTTACGTCGGGTCTGAAGGAC
GGGGACAAGGTGGTTGTGGAAGGCATCAGTATCGCCGGTATAACGGGTGCGAAAAAGGTAACGCCCAAAGAATGGGCGTCGTCTGAAAAC
CAAGCCGCCGCGCCTCAATCCGGCGTTCAGACGGCATCTGAAGCCAAACCTGCTTCTGAAGCGAAATAA