mtrA

Accession ARO:3000816
CARD Short NamemtrA
DefinitionMtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesNeisseria gonorrhoeaeg+p+wgs
Resistomes with Sequence VariantsNeisseria gonorrhoeaeg+p+wgs, Neisseria meningitidisg+wgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Rouquette C, et al. 1999. Mol Microbiol 33(3): 651-658. Induction of the mtrCDE-encoded efflux pump system of Neisseria gonorrhoeae requires MtrA, an AraC-like protein. (PMID 10417654)

Resistomes

Prevalence of mtrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Neisseria gonorrhoeae98.75%1.02%99.56%0%0%
Neisseria meningitidis100%0%98.76%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AAD44693.1|+|mtrA [Neisseria gonorrhoeae]
MDILDKLVDLAQLTGSADVQCLLGGQWSVRHETLQCEGLVHIVTAGSGYLCIDGETSPRPVGTGDIVFFPRGLGHVLSHDGKYGESLQPD
IRQNGTFMVKQCGNGLDMSLFCARFRYDTHADLMNGLPETVFLNIAHPSLQYVVSMLQLESEKPLTGTVSVVNALPSVLLVLILRAYLEQ
DKDVELSGVLKGWQDKRLGHLIQKVIDKPEDEWNIDKMVAAANMSRAQLMRRFKSQVGLSPHAFVNHIRLQKGALLLKKTPDSVLEVALS
VGFQSETHFGKAFKRQYHVSPGQYRKEGGQK


>gb|AF128627.1|+|1-906|mtrA [Neisseria gonorrhoeae]
ATGGACATTCTGGACAAACTGGTCGATCTCGCCCAATTGACGGGCAGTGCGGATGTGCAGTGCCTTTTGGGCGGACAATGGTCGGTACGG
CATGAAACCTTGCAATGCGAAGGGCTGGTACACATTGTTACGGCGGGCAGCGGTTATCTCTGCATCGACGGCGAAACTTCCCCGCGTCCG
GTCGGCACGGGCGATATTGTATTTTTCCCGCGCGGCTTGGGTCATGTGTTGAGCCACGACGGAAAATACGGAGAAAGTTTACAACCGGAC
ATACGACAAAACGGCACATTTATGGTCAAACAGTGCGGCAACGGGCTGGATATGAGCCTGTTTTGCGCCCGTTTCCGCTACGACACCCAC
GCCGATTTGATGAACGGGCTGCCGGAAACCGTTTTTCTGAACATTGCCCATCCAAGTTTGCAGTATGTGGTTTCAATGCTGCAACTGGAA
AGCGAAAAACCTTTGACGGGGACGGTTTCCGTGGTCAACGCATTACCGTCCGTCCTGCTGGTGCTTATCCTGCGCGCCTATCTCGAACAG
GATAAGGATGTCGAACTCTCGGGCGTATTGAAAGGTTGGCAGGACAAACGTTTGGGACATTTGATCCAAAAGGTGATAGACAAACCGGAA
GACGAATGGAATATTGACAAAATGGTTGCCGCCGCCAATATGTCGCGCGCGCAACTGATGCGCCGCTTCAAAAGCCAAGTCGGACTCAGC
CCGCACGCCTTTGTGAACCATATCCGCCTGCAAAAAGGCGCATTGCTGCTGAAGAAAACCCCGGATTCGGTTTTGGAGGTCGCGCTGTCG
GTGGGCTTTCAGTCGGAAACGCATTTCGGCAAGGCGTTCAAACGGCAATATCACGTTTCGCCGGGGCAATACCGGAAAGAAGGCGGGCAA
AAATAA

Curator Acknowledgements
Curator Description Most Recent Edit