| Accession | ARO:3000816 |
| CARD Short Name | mtrA |
| Definition | MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | penam, macrolide antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Perfect Matches | Neisseria gonorrhoeaeg+p+wgs |
| Resistomes with Sequence Variants | Neisseria gonorrhoeaeg+p+wgs, Neisseria meningitidisg+wgs |
| Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + penam [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + macrolide antibiotic [Drug Class] + erythromycin [Antibiotic] + penicillin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + azithromycin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + regulates MtrCDE |
| Publications | Rouquette C, et al. 1999. Mol Microbiol 33(3): 651-658. Induction of the mtrCDE-encoded efflux pump system of Neisseria gonorrhoeae requires MtrA, an AraC-like protein. (PMID 10417654) |
Prevalence of mtrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Neisseria gonorrhoeae | 98.75% | 1.02% | 75.89% | 0% |
| Neisseria meningitidis | 100% | 0% | 89.69% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400