MdsABC

Accession ARO:3000786
Synonym(s)GesABC STM0352 STM0351 STM0350
DefinitionMdsABC, or GesABC, is a RND-type efflux complex found in Salmonella. In addition to its metal-efflux system, GesABC is also capable of exporting beta-lactams, chloramphenicol, and thiamphenicol. GesB is the inner membrane transporter and is similar to MexF; GesA is the membrane-fusion protein, and GesC is the outer membrane factor.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, carbapenem, antibacterial free fatty acids, acridine dye, glycylcycline, aminoglycoside antibiotic, fluoroquinolone antibiotic, penam, monobactam, triclosan, aminocoumarin antibiotic, diaminopyrimidine antibiotic, macrolide antibiotic, cephalosporin, cephamycin, penem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification23 ontology terms | Show
Parent Term(s)8 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_drug_class monobactam [Drug Class]
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class cephamycin [Drug Class]
+ confers_resistance_to_drug_class penem [Drug Class]
Sub-Term(s)
4 ontology terms | Show
+ mdsA part_of
+ mdsB part_of
+ mdsC part_of
+ golS regulates
Publications

Conroy O, et al. 2010. FEMS Microbiol Lett 308(2): 115-122. Differing ability to transport nonmetal substrates by two RND-type metal exporters. (PMID 20497225)

Pontel LB, et al. 2007. Mol Microbiol 66(3): 814-825. GolS controls the response to gold by the hierarchical induction of Salmonella-specific genes that include a CBA efflux-coding operon. (PMID 17919284)