Accession ARO:3000786
Synonym(s)GesABC STM0352 STM0351 STM0350
DefinitionMdsABC, or GesABC, is a RND-type efflux complex found in Salmonella. In addition to its metal-efflux system, GesABC is also capable of exporting beta-lactams, chloramphenicol, and thiamphenicol. GesB is the inner membrane transporter and is similar to MexF; GesA is the membrane-fusion protein, and GesC is the outer membrane factor.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classphenicol antibiotic, monobactam, carbapenem, penam, cephalosporin, cephamycin, penem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification9 ontology terms | Show
Parent Term(s)8 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_drug_class monobactam [Drug Class]
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class cephamycin [Drug Class]
+ confers_resistance_to_drug_class penem [Drug Class]
4 ontology terms | Show
+ mdsA part_of
+ mdsB part_of
+ mdsC part_of
+ golS regulates

Conroy O, et al. 2010. FEMS Microbiol Lett 308(2): 115-122. Differing ability to transport nonmetal substrates by two RND-type metal exporters. (PMID 20497225)

Pontel LB, et al. 2007. Mol Microbiol 66(3): 814-825. GolS controls the response to gold by the hierarchical induction of Salmonella-specific genes that include a CBA efflux-coding operon. (PMID 17919284)