mdsA

Accession ARO:3000789
Synonym(s)gesA
CARD Short NamemdsA
DefinitionMdsA is the membrane fusion protein of the multidrug and metal efflux complex MdsABC.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classphenicol antibiotic, penam, monobactam, cephamycin, cephalosporin, penem, carbapenem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesSalmonella entericag+wgs+gi
Resistomes with Sequence VariantsSalmonella entericag+wgs+gi
Classification17 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Pontel LB, et al. 2007. Mol Microbiol 66(3): 814-825. GolS controls the response to gold by the hierarchical induction of Salmonella-specific genes that include a CBA efflux-coding operon. (PMID 17919284)

Conroy O, et al. 2010. FEMS Microbiol Lett 308(2): 115-122. Differing ability to transport nonmetal substrates by two RND-type metal exporters. (PMID 20497225)

Resistomes

Prevalence of mdsA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Salmonella enterica32.93%0%32.93%41.72%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 770


>gb|AAL19306.1|-|mdsA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MRRTFKIMLIAGVIAAIGGVIYMAGEALWDKDNAVGPPASAPPPPSVPVAKALSRTLAPTAEFTGFLAAPETVELRSRVGGTLDAISVPE
GRLVSRGQLLFQIDPRPFEVALDTAVAQLRQAEVLARQAQADFDRIQRLVASGAVSRKNADDVTATRNARQAQMQSAKAAVAAARLELSW
TRITAPIAGRVDRILVTRGNLVSGGVAGNATLLTTIVSHNPMYVYFDIDEATWLKALRHTRSDKNPPVVNMGLTTDNGLPYQGVLDFMGN
QMNRSTGTIRARAVIPDPDGMLSPGLFARISLPIGEPRETVLIDDLAVSADQGKNYVLIVGKENQVEYRPVELGQMVDGFRVVTQGVLPG
EKIILKGLVRPGMTVAPRLVPMRQNVTDKQTATLTKADGDSAPKAVRQ


>gb|AE006468.2|-|397058-398284|mdsA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGCGTAGAACATTCAAAATTATGTTGATAGCCGGCGTCATCGCCGCCATCGGGGGCGTGATTTACATGGCCGGCGAAGCACTATGGGAT
AAAGACAACGCCGTCGGCCCCCCGGCCAGCGCGCCGCCTCCACCGTCGGTACCGGTTGCTAAAGCCCTTAGCCGTACACTCGCGCCTACG
GCGGAATTCACCGGTTTTCTGGCCGCGCCGGAAACCGTGGAGCTGCGTTCGCGCGTGGGAGGAACCCTTGACGCCATCAGCGTTCCGGAA
GGACGTCTGGTAAGCCGCGGACAACTGCTGTTCCAGATCGATCCGCGCCCGTTCGAGGTCGCCCTCGACACCGCCGTCGCGCAATTACGT
CAGGCTGAAGTACTGGCCCGCCAGGCGCAGGCGGATTTCGATCGCATTCAACGACTGGTCGCCAGCGGCGCCGTATCACGTAAAAACGCT
GACGATGTCACCGCCACGCGTAATGCGCGACAGGCGCAGATGCAATCGGCCAAAGCCGCCGTCGCCGCAGCGCGCCTTGAACTCTCCTGG
ACCCGTATTACCGCGCCCATTGCCGGACGCGTTGACCGCATACTGGTGACCCGGGGCAATCTGGTCAGCGGCGGCGTAGCGGGTAACGCC
ACGCTTCTGACGACTATCGTGTCTCACAATCCCATGTATGTGTATTTCGATATTGACGAAGCCACCTGGCTGAAGGCGTTACGGCATACC
CGCTCCGACAAAAATCCACCGGTAGTCAACATGGGGTTAACCACCGATAACGGGCTGCCTTATCAGGGCGTACTCGACTTTATGGGCAAT
CAGATGAACCGCAGCACCGGCACTATCCGGGCACGCGCCGTGATTCCTGACCCCGACGGAATGCTTTCTCCCGGCCTGTTTGCCCGAATC
AGTTTGCCCATCGGCGAGCCGCGGGAAACCGTGCTGATTGACGATCTGGCGGTGAGCGCCGATCAGGGCAAAAACTATGTGCTGATCGTC
GGCAAGGAGAATCAGGTGGAGTATCGTCCGGTTGAGTTGGGACAAATGGTCGATGGATTCCGCGTCGTTACACAGGGAGTACTGCCGGGA
GAAAAAATCATCCTCAAGGGGCTGGTGCGTCCTGGCATGACCGTTGCGCCACGTCTGGTGCCGATGCGGCAGAATGTGACCGACAAACAG
ACCGCGACATTGACTAAAGCGGACGGCGACAGTGCGCCGAAGGCGGTGCGCCAATGA