| Accession | ARO:3000504 |
| CARD Short Name | golS |
| Definition | GolS is a regulator activated by the presence of golD, and promotes the expression of the MdsABC efflux pump. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | phenicol antibiotic, cephamycin, monobactam, cephalosporin, penem, penam, carbapenem |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Perfect Matches | Salmonella entericag+wgs |
| Resistomes with Sequence Variants | Salmonella bongorig, Salmonella entericag+wgs+gi |
| Classification | 17 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + determinant of antibiotic resistance + beta-lactam antibiotic + antibiotic efflux [Resistance Mechanism] + cephem + phenicol antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + cephamycin [Drug Class] + monobactam [Drug Class] + chloramphenicol [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + cephalosporin [Drug Class] + penem [Drug Class] + penam [Drug Class] + carbapenem [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + regulates MdsABC |
| Publications | Pontel LB, et al. 2007. Mol Microbiol 66(3): 814-825. GolS controls the response to gold by the hierarchical induction of Salmonella-specific genes that include a CBA efflux-coding operon. (PMID 17919284) Perez Audero ME, et al. 2010. Mol Microbiol 78(4): 853-865. Target transcription binding sites differentiate two groups of MerR-monovalent metal ion sensors. (PMID 20807206) |
Prevalence of golS among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Salmonella bongori | 8.33% | 0% | 0% | 0% |
| Salmonella enterica | 85.36% | 0% | 74.4% | 37.09% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 290