antibiotic sensitive enoyl-acyl carrier reductase

Accession ARO:3000872
DefinitionEnoyl-acyl carrier reductases catalyze the final enoyl reduction step in bacterial type II fatty acid elongation. Triclosan antibiotics block enoyl reduction and therefore fatty acid synthesis, functioning as a broad spectrum biocide and antibiotic.
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ fatty acid synthesis enzyme targeted by antibiotic
+ targeted_by_antibiotic triclosan [Antibiotic]
4 ontology terms | Show

Sivaraman S, et al. 2004. J Med Chem 47(3): 509-518. Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues. (PMID 14736233)