ICR-Mo

Accession ARO:3004569
DefinitionA chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella osloensis. ICR-Mo represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases
AMR Gene Familyintrinsic colistin resistant phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification13 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ intrinsic colistin resistant phosphoethanolamine transferase [AMR Gene Family]
Publications

Wei W, et al. 2018. PLoS Genet. 14(5):e1007389 Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis. (PMID 29758020)

Resistomes

Prevalence of ICR-Mo among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 600


>gb|WP_082741435.1|+|ICR-Mo [Moraxella osloensis]
MVHLDKVSNRMSVNNSRWLAWRQQGINAYVMMGIVALFLTLTANITFFDKATEVYPFAQHIGFIGSLPLVLFGVMLLVIVLLSYRYTLKA
VLIFLLLTAAVTAYFTDTYGTVYDVNMLQNALQTDKAESADLFNVNFILRILLLGVLPSVWVAWQKVTFPPIKRSILQRGLTYLVSLGLV
VLPILAMSKNYASFFREHKQLRSYTNPATPVYALGKLASIQLKQAQAPKTQIMHATDAVQVSNPTTRKPKLVVFVVGETARGDHVQLNGY
NRTTFPQMAATAGVTNFNQVIACGTSTAYSVPCMFSYVGMKDYDVDTANYQENVLDTLHRLKVNILWRDNNSSSKGVTNRLPAADFVDYK
TARNNTMCNTNPYGECRDVGMLVGLDDYVKQQANQNTLNQDTLIVLHQMGNHGPAYFKRYDKQFEKFTPVCQSNELAKCDPQSVINAFDN
ALLATDDFLAKTVNWLDKYDSTHQVAMLYVSDHGESLGENGIYLHGMPYKIAPKAQKHVASMFWAGKHSGIQAVPSNTELTHDAITPTLL
KLFDVRAQTVQGKPLFIK


>gb|NZ_CP014234.1|+|1701630-1703306|ICR-Mo [Moraxella osloensis]
TTGGTGCATTTAGATAAGGTGAGTAATCGTATGTCAGTGAATAACTCTCGATGGTTAGCATGGCGTCAGCAAGGTATTAATGCTTATGTG
ATGATGGGTATTGTCGCGCTATTTTTGACCCTAACCGCCAATATTACTTTCTTTGATAAAGCCACGGAAGTCTATCCGTTTGCCCAGCAT
ATTGGGTTTATAGGCTCATTGCCGTTGGTGCTATTCGGTGTCATGCTACTGGTTATTGTGCTGCTCAGCTATCGTTACACCCTTAAAGCG
GTATTGATTTTTTTGCTATTGACCGCGGCAGTCACGGCGTATTTTACTGATACTTATGGCACTGTCTATGATGTCAATATGCTACAAAAC
GCGCTACAAACCGATAAAGCAGAAAGCGCCGATTTGTTTAACGTCAATTTTATCTTACGCATTTTATTGCTTGGGGTATTGCCTAGTGTG
TGGGTGGCGTGGCAAAAGGTCACATTTCCCCCCATCAAGCGCAGCATATTGCAGCGCGGCTTGACGTATTTGGTCAGCCTCGGTTTGGTA
GTGTTACCGATTTTGGCAATGAGTAAAAATTACGCCAGTTTTTTCCGTGAACATAAACAGCTTCGTAGCTATACCAATCCTGCAACCCCT
GTATATGCACTGGGTAAACTTGCCAGTATACAGCTCAAACAAGCACAAGCTCCCAAAACCCAAATCATGCATGCCACCGATGCGGTGCAG
GTGAGTAATCCTACCACCCGTAAGCCAAAACTGGTGGTATTTGTAGTTGGAGAAACCGCGCGCGGCGACCATGTGCAGCTAAATGGGTAT
AACCGAACTACCTTCCCGCAGATGGCAGCGACGGCTGGGGTAACTAATTTTAACCAAGTCATCGCCTGCGGTACCTCAACCGCTTATTCG
GTGCCTTGTATGTTTAGTTATGTCGGCATGAAAGACTACGATGTGGATACCGCCAACTACCAAGAAAACGTACTTGATACCTTACATCGC
CTAAAGGTTAATATCTTGTGGCGTGATAACAACTCAAGCTCAAAAGGCGTCACTAATCGTTTGCCCGCGGCGGATTTTGTCGATTATAAA
ACTGCGCGCAACAATACGATGTGTAATACCAACCCCTATGGCGAGTGCCGCGATGTGGGTATGCTAGTAGGCTTAGATGACTACGTCAAA
CAACAAGCTAACCAAAATACGCTTAACCAGGATACCCTAATTGTGCTGCACCAAATGGGTAATCACGGACCTGCGTATTTTAAACGATAT
GATAAGCAATTTGAAAAATTCACCCCAGTCTGCCAAAGCAATGAACTTGCCAAATGCGACCCACAAAGCGTGATTAATGCCTTTGACAAT
GCGCTACTTGCCACCGATGACTTTTTGGCAAAAACGGTGAACTGGTTAGACAAATATGACAGCACCCACCAAGTAGCGATGCTGTATGTC
AGTGACCACGGTGAAAGTCTGGGCGAAAACGGCATCTATTTACATGGTATGCCTTATAAAATCGCGCCTAAAGCGCAAAAACACGTCGCA
TCGATGTTTTGGGCAGGTAAACACTCAGGCATTCAAGCAGTGCCATCTAATACTGAGCTCACCCATGATGCCATTACCCCAACCTTGTTA
AAACTGTTTGATGTGCGTGCGCAAACCGTACAAGGCAAACCTTTATTTATCAAGTAA