| Accession | ARO:3004588 |
| Synonym(s) | C8T8U1 |
| CARD Short Name | Kpne_KpnG |
| Definition | KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | peptide antibiotic, aminoglycoside antibiotic, macrolide antibiotic, fluoroquinolone antibiotic, penam, carbapenem, cephalosporin, penem |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Klebsiella pneumoniaeg+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Bacillus thuringiensiswgs, Burkholderia cepaciawgs, Burkholderia contaminanswgs, Enterobacter asburiaewgs, Escherichia coliwgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Raoultella planticolag+wgs, Serratia marcescenswgs |
| Classification | 39 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + beta-lactam antibiotic + lipopeptide antibiotic + mechanism of antibiotic resistance + polymyxin antibiotic + antibiotic mixture + cephem + aminoglycoside antibiotic [Drug Class] + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + polymyxin B [Antibiotic] + macrolide antibiotic [Drug Class] + fluoroquinolone antibiotic [Drug Class] + penam [Drug Class] + carbapenem [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + cephalosporin [Drug Class] + penem [Drug Class] + gentamicin [Antibiotic] + ertapenem [Antibiotic] + erythromycin [Antibiotic] + norfloxacin [Antibiotic] + polymyxin B2 [Antibiotic] + polymyxin B3 [Antibiotic] + ticarcillin [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + piperacillin [Antibiotic] + ceftazidime [Antibiotic] + spectinomycin [Antibiotic] + polymyxin B1 [Antibiotic] + streptomycin [Antibiotic] + azithromycin [Antibiotic] + imipenem [Antibiotic] + tobramycin [Antibiotic] + polymyxin B4 [Antibiotic] + ciprofloxacin [Antibiotic] + gentamicin C [Antibiotic] |
| Parent Term(s) | 3 ontology terms | Show + part_of Klebsiella pneumoniae KpnGH-TolC + subunit of efflux pump conferring antibiotic resistance + confers_resistance_to_drug_class cephalosporin [Drug Class] |
| Publications | Srinivasan VB, et al. 2014. PLoS ONE 9(5):e96288 Role of novel multidrug efflux pump involved in drug resistance in Klebsiella pneumoniae. (PMID 24823362) |
Prevalence of Klebsiella pneumoniae KpnG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.03% | 0% |
| Bacillus thuringiensis | 0% | 0% | 0.16% | 0% |
| Burkholderia cepacia | 0% | 0% | 0.45% | 0% |
| Burkholderia contaminans | 0% | 0% | 1.28% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.44% | 0% |
| Escherichia coli | 0% | 0% | 0.02% | 0% |
| Klebsiella aerogenes | 100% | 0% | 79.32% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 50% | 0% |
| Klebsiella michiganensis | 100% | 0% | 71.94% | 0% |
| Klebsiella oxytoca | 100% | 0% | 83.33% | 0% |
| Klebsiella pneumoniae | 99.34% | 0.03% | 66.22% | 0% |
| Klebsiella quasipneumoniae | 100% | 0% | 80.59% | 0% |
| Raoultella planticola | 100% | 0% | 94.44% | 0% |
| Serratia marcescens | 0% | 0% | 0.14% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700