ertapenem [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:0000070
Synonym(s)ERT Invanz
DefinitionErtapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.
SMILESC[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)Nc4cccc(C(=O)O)c4)C3)[C@H](C)[C@H]12
PubChem150610
ChEMBLCHEMBL1359
ChEBI404903
CAS153832-46-3
Drug Classcarbapenem
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ carbapenem [Drug Class]
Sub-Term(s)
10 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ NDM-1 confers_resistance_to_antibiotic
+ NDM-5 confers_resistance_to_antibiotic
+ CTX-M-27 confers_resistance_to_antibiotic
+ CMY-2 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic
+ VIM-63 confers_resistance_to_antibiotic
+ VCC-1 confers_resistance_to_antibiotic
+ FRI-11 confers_resistance_to_antibiotic
Publications

Shah PM and Isaacs RD. 2003. J Antimicrob Chemother 52(4): 538-542. Ertapenem, the first of a new group of carbapenems. (PMID 12951340)

Sakoulas G, et al. 2016. Antimicrob. Agents Chemother. : Cefazolin and Ertapenem: A Synergistic Combination Used to Clear Persistent Staphylococcus aureus Bacteremia. (PMID 27572414)

Curator Acknowledgements
Curator Description Most Recent Edit