| Accession | ARO:3002013 |
| Synonym(s) | BIL-1, LAT-2 |
| CARD Short Name | CMY-2 |
| Definition | CMY-2 is a beta-lactamase found in Klebsiella pneumoniae. |
| AMR Gene Family | CMY beta-lactamase |
| Drug Class | cephalosporin, cephamycin, penam, carbapenem |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Aeromonas hydrophilap, Citrobacter freundiig+p+wgs, Citrobacter portucalensisg+wgs, Escherichia albertiiwgs, Escherichia colig+p+wgs+gi, Klebsiella aerogeneswgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Proteus mirabilisg+wgs, Proteus vulgariswgs, Providencia rettgeriwgs, Providencia stuartiip, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella flexneriwgs, Shigella sonneiwgs, Vibrio choleraep+wgs |
| Resistomes with Sequence Variants | Aeromonas hydrophilap, Citrobacter freundiig+p+wgs, Citrobacter portucalensisg+wgs, Escherichia albertiiwgs, Escherichia colig+p+wgs+gi, Klebsiella aerogeneswgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Proteus mirabilisg+wgs, Proteus vulgariswgs, Providencia rettgeriwgs, Providencia stuartiip, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella flexneriwgs, Shigella sonneiwgs, Vibrio choleraep+wgs |
| Classification | 19 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + beta-lactam antibiotic + class C beta-lactamase + cephem + CMY-LAT-MOX beta-lactamase + cephalosporin [Drug Class] + cephamycin [Drug Class] + penam [Drug Class] + CMY-LAT beta-lactamase + CMY-MOX beta-lactamase + carbapenem [Drug Class] |
| Parent Term(s) | 10 ontology terms | Show + CMY beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic cephamycin [Drug Class] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic cefoxitin [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + confers_resistance_to_antibiotic cefazolin [Antibiotic] + confers_resistance_to_antibiotic cefixime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] + confers_resistance_to_antibiotic cefalotin [Antibiotic] + confers_resistance_to_antibiotic ertapenem [Antibiotic] |
| Sub-Term(s) | 3 ontology terms | Show + vaborbactam [Adjuvant] is_small_molecule_inhibitor + taniborbactam [Adjuvant] is_small_molecule_inhibitor + nacubactam [Adjuvant] is_small_molecule_inhibitor |
| Publications | Bauernfeind A, et al. 1996. Antimicrob Agents Chemother 40(1): 221-224. Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance. (PMID 8787910) Tsang KK, et al. 2021. Microb Genom 7(1): Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance. (PMID 33416461) |
Prevalence of CMY-2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas hydrophila | 0% | 2.6% | 0% | 0% |
| Citrobacter freundii | 0.82% | 0.31% | 0.58% | 0% |
| Citrobacter portucalensis | 3.7% | 0% | 6.31% | 0% |
| Escherichia albertii | 0% | 0% | 0.65% | 0% |
| Escherichia coli | 1.29% | 0.52% | 2.68% | 1.79% |
| Klebsiella aerogenes | 0% | 0% | 0.28% | 0% |
| Klebsiella pneumoniae | 0% | 0.16% | 0.3% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0.66% | 0% |
| Proteus mirabilis | 9.17% | 0% | 3.47% | 0% |
| Proteus vulgaris | 0% | 0% | 5.56% | 0% |
| Providencia rettgeri | 0% | 0% | 3.18% | 0% |
| Providencia stuartii | 0% | 2.27% | 0% | 0% |
| Salmonella enterica | 0.44% | 6.13% | 4.65% | 0.33% |
| Shigella boydii | 0% | 0% | 3.33% | 0% |
| Shigella flexneri | 0% | 0% | 0.16% | 0% |
| Shigella sonnei | 0% | 0% | 0.22% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.06% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700