| Accession | ARO:3003713 |
| CARD Short Name | VCC-1 |
| Definition | VCC-1 is a Class A carbapenemase isolated from Vibrio cholerae and exhibits resistance to penicillins, carbapenems and monobactam antibiotics. |
| AMR Gene Family | VCC beta-lactamase |
| Drug Class | carbapenem, monobactam, penam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Vibrio choleraewgs |
| Resistomes with Sequence Variants | Vibrio choleraewgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + hydrolysis of antibiotic conferring resistance + antibiotic inactivation enzyme + beta-lactam antibiotic + beta-lactamase + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + carbapenem [Drug Class] + monobactam [Drug Class] + penam [Drug Class] + class A beta-lactamase |
| Parent Term(s) | 6 ontology terms | Show + VCC beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic ertapenem [Antibiotic] + confers_resistance_to_antibiotic doripenem [Antibiotic] + confers_resistance_to_antibiotic aztreonam [Antibiotic] + confers_resistance_to_antibiotic imipenem [Antibiotic] + confers_resistance_to_antibiotic meropenem [Antibiotic] |
| Publications | Mangat CS, et al. 2016. Antimicrob. Agents Chemother. 60(3):1819-25 Characterization of VCC-1, a Novel Ambler Class A Carbapenemase from Vibrio cholerae Isolated from Imported Retail Shrimp Sold in Canada. (PMID 26824956) |
Prevalence of VCC-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Vibrio cholerae | 0% | 0% | 0.26% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 550