aztreonam [Antibiotic]

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Accession ARO:3000550
Synonym(s)Primbactam ATM
DefinitionAztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.
Drug Classmonobactam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ monobactam [Drug Class]
9 ontology terms | Show

Sykes RB and Bonner DP. 1985. Am J Med 78(2A): 2-10. Aztreonam: the first monobactam. (PMID 3871589)