aztreonam [Antibiotic]

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Accession ARO:3000550
Synonym(s)ATM Primbactam
DefinitionAztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.
Drug Classmonobactam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ monobactam [Drug Class]
12 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic
+ MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic
+ MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic
+ MuxABC-OpmB confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ VCC-1 confers_resistance_to_antibiotic
+ Escherichia coli PBP3 mutants conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic
+ aztreonam-clavulanate [Antibiotic+Adjuvant] has_part
+ aztreonam-tazobactam [Antibiotic+Adjuvant] has_part
+ aztreonam-avibactam [Antibiotic+Adjuvant] has_part

Sykes RB and Bonner DP. 1985. Am J Med 78(2A): 2-10. Aztreonam: the first monobactam. (PMID 3871589)