| Accession | ARO:3000550 |
| Synonym(s) | ATM Primbactam |
| Definition | Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death. |
| Drug Class | monobactam |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + monobactam [Drug Class] |
| Sub-Term(s) | 16 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + MexAB-OprM confers_resistance_to_antibiotic + MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic + MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic + MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic + MuxABC-OpmB confers_resistance_to_antibiotic + MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic + VCC-1 confers_resistance_to_antibiotic + Escherichia coli PBP3 mutants conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + Pseudomonas aeruginosa ampR with mutation conferring resistance to aztreonam confers_resistance_to_antibiotic + ACC-1 confers_resistance_to_antibiotic + ACC-4 confers_resistance_to_antibiotic + TEM-61 confers_resistance_to_antibiotic + aztreonam-clavulanate [Antibiotic+Adjuvant] has_part + aztreonam-tazobactam [Antibiotic+Adjuvant] has_part + aztreonam-avibactam [Antibiotic+Adjuvant] has_part |
| Publications | Sykes RB and Bonner DP. 1985. Am J Med 78(2A): 2-10. Aztreonam: the first monobactam. (PMID 3871589) |
