| Accession | ARO:3004597 |
| Synonym(s) | A0A3F3BH25 |
| CARD Short Name | Kpne_KpnH |
| Definition | KpnH consists of ~511 residues, resembles EmrB of E. coli, and is probably a translocase in the KpnGH-TolC efflux protein in K. pneumoniae. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | peptide antibiotic, aminoglycoside antibiotic, penem, macrolide antibiotic, penam, cephalosporin, carbapenem, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Escherichia albertiig, Escherichia colig+wgs, Shigella flexneriwgs |
| Resistomes with Sequence Variants | Avibacterium paragallinarumg+wgs, Citrobacter freundiig+wgs, Citrobacter werkmaniig, Cronobacter condimentig+wgs, Cronobacter dublinensisg+wgs, Edwardsiella tardag+wgs, Enterobacter asburiaewgs, Enterobacter cloacaeg+wgs, Enterobacter hormaecheig+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia albertiig+wgs, Escherichia colig+wgs, Escherichia marmotaewgs, Haemophilus influenzaeg+wgs, Haemophilus parainfluenzaeg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leminorella grimontiiwgs, Morganella morganiig+wgs, Pectobacterium parmentierig+wgs, Photorhabdus asymbioticag+wgs, Plesiomonas shigelloidesg+wgs, Proteus columbaeg+wgs, Proteus mirabilisg+wgs, Proteus pennerig+wgs, Proteus vulgarisg+wgs, Providencia alcalifaciensg+p+wgs, Providencia heimbachaeg+wgs, Providencia rettgerig+wgs, Providencia stuartiig+wgs, Raoultella planticolag+wgs, Salmonella entericag+wgs, Serratia liquefaciensg+wgs, Serratia marcescensg+p+wgs, Serratia odoriferag+wgs, Serratia rubidaeag+wgs, Shigella boydiig, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneiwgs, Yersinia canariaeg+wgs, Yersinia enterocoliticag+wgs, Yersinia kristenseniig+wgs, Yersinia pestisg+wgs, Yersinia pseudotuberculosisg+wgs |
| Classification | 39 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + beta-lactam antibiotic + lipopeptide antibiotic + mechanism of antibiotic resistance + antibiotic mixture + aminoglycoside antibiotic [Drug Class] + polymyxin antibiotic + cephem + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + penem [Drug Class] + macrolide antibiotic [Drug Class] + penam [Drug Class] + polymyxin B [Antibiotic] + cephalosporin [Drug Class] + carbapenem [Drug Class] + gentamicin [Antibiotic] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + fluoroquinolone antibiotic [Drug Class] + polymyxin B4 [Antibiotic] + polymyxin B2 [Antibiotic] + ceftazidime [Antibiotic] + streptomycin [Antibiotic] + norfloxacin [Antibiotic] + polymyxin B1 [Antibiotic] + azithromycin [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + spectinomycin [Antibiotic] + ciprofloxacin [Antibiotic] + erythromycin [Antibiotic] + ticarcillin [Antibiotic] + imipenem [Antibiotic] + piperacillin [Antibiotic] + gentamicin C [Antibiotic] + polymyxin B3 [Antibiotic] + ertapenem [Antibiotic] + tobramycin [Antibiotic] |
| Parent Term(s) | 3 ontology terms | Show + subunit of efflux pump conferring antibiotic resistance + part_of Klebsiella pneumoniae KpnGH-TolC + confers_resistance_to_drug_class cephalosporin [Drug Class] |
| Publications | Srinivasan VB, et al. 2014. PLoS ONE 9(5):e96288 Role of novel multidrug efflux pump involved in drug resistance in Klebsiella pneumoniae. (PMID 24823362) |
Prevalence of Klebsiella pneumoniae KpnH among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Avibacterium paragallinarum | 100% | 0% | 47.06% | 0% |
| Citrobacter freundii | 21.31% | 0% | 0.97% | 0% |
| Citrobacter werkmanii | 28.57% | 0% | 0% | 0% |
| Cronobacter condimenti | 100% | 0% | 50% | 0% |
| Cronobacter dublinensis | 33.33% | 0% | 15.38% | 0% |
| Edwardsiella tarda | 100% | 0% | 93.33% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.79% | 0% |
| Enterobacter cloacae | 1.79% | 0% | 1.28% | 0% |
| Enterobacter hormaechei | 0.36% | 0% | 0.35% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 2.16% | 0% |
| Escherichia albertii | 11.43% | 0% | 2.58% | 0% |
| Escherichia coli | 0.29% | 0% | 0.56% | 0% |
| Escherichia marmotae | 0% | 0% | 2.08% | 0% |
| Haemophilus influenzae | 19.59% | 0% | 10.17% | 0% |
| Haemophilus parainfluenzae | 68.75% | 0% | 21.95% | 0% |
| Klebsiella aerogenes | 100% | 0% | 79.66% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 66.67% | 0% |
| Klebsiella michiganensis | 100% | 0% | 69.41% | 0% |
| Klebsiella oxytoca | 100% | 0% | 75.21% | 0% |
| Klebsiella pneumoniae | 99.41% | 0.02% | 57.29% | 0% |
| Klebsiella quasipneumoniae | 100% | 0% | 73.82% | 0% |
| Kosakonia arachidis | 100% | 0% | 100% | 0% |
| Leminorella grimontii | 0% | 0% | 85.71% | 0% |
| Morganella morganii | 100% | 0% | 55.21% | 0% |
| Pectobacterium parmentieri | 100% | 0% | 94.12% | 0% |
| Photorhabdus asymbiotica | 100% | 0% | 100% | 0% |
| Plesiomonas shigelloides | 75% | 0% | 86.21% | 0% |
| Proteus columbae | 100% | 0% | 100% | 0% |
| Proteus mirabilis | 100% | 0% | 42.24% | 0% |
| Proteus penneri | 100% | 0% | 100% | 0% |
| Proteus vulgaris | 90.91% | 0% | 88.89% | 0% |
| Providencia alcalifaciens | 90.91% | 4% | 96.55% | 0% |
| Providencia heimbachae | 100% | 0% | 71.43% | 0% |
| Providencia rettgeri | 100% | 0% | 53.5% | 0% |
| Providencia stuartii | 100% | 0% | 68.18% | 0% |
| Raoultella planticola | 100% | 0% | 94.87% | 0% |
| Salmonella enterica | 0.57% | 0% | 0.55% | 0% |
| Serratia liquefaciens | 100% | 0% | 50.79% | 0% |
| Serratia marcescens | 98.48% | 0.65% | 77.85% | 0% |
| Serratia odorifera | 100% | 0% | 100% | 0% |
| Serratia rubidaea | 100% | 0% | 90.91% | 0% |
| Shigella boydii | 6.67% | 0% | 0% | 0% |
| Shigella dysenteriae | 71.43% | 0% | 20% | 0% |
| Shigella flexneri | 1% | 0% | 0.62% | 0% |
| Shigella sonnei | 0% | 0% | 0.37% | 0% |
| Yersinia canariae | 100% | 0% | 50% | 0% |
| Yersinia enterocolitica | 100% | 0% | 75.45% | 0% |
| Yersinia kristensenii | 100% | 0% | 65.71% | 0% |
| Yersinia pestis | 98.46% | 0% | 77.93% | 0% |
| Yersinia pseudotuberculosis | 100% | 0% | 100% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700