TUS-1

Accession ARO:3000844
CARD Short NameTUS-1
DefinitionTUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus.
AMR Gene FamilyTUS beta-lactamase
Drug Classcephamycin, carbapenem, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification16 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic amoxicillin [Antibiotic]
+ confers_resistance_to_antibiotic piperacillin [Antibiotic]
+ confers_resistance_to_antibiotic ticarcillin [Antibiotic]
+ TUS beta-lactamase [AMR Gene Family]
Publications

Mammeri H, et al. 2002. Antimicrob Agents Chemother 46(11): 3561-3567. Chromosome-encoded beta-lactamases TUS-1 and MUS-1 from Myroides odoratus and Myroides odoratimimus (formerly Flavobacterium odoratum), new members of the lineage of molecular subclass B1 metalloenzymes. (PMID 12384365)

Resistomes

Prevalence of TUS-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 450


>gb|AAN63648.1|+|TUS-1 [Myroides odoratus DSM 2801]
MYHYFSSLFVLIFSTLVYPQSDKLKIEPLNDHMYVYTTYQVFQGVEYSSNALYVVTDEGVILIDTPWDKDQYAPLVEHIRREHNKEIKWV
ITTHFHEDRSGGLDYFNKAGAETYTYALTNEILKQRNEPQATFTFGSTKQFNLGKEKIEVYFLGEGHSKDNTVVWFPEEAILYGGCLIKS
AEATTIGNIVDGNVEAWPTTIKAVKRKFKKAKVIIPGHDAWNQSGHLENTARILSAYQAQKLKNNKQL


>gb|AF441287.1|+|261-1007|TUS-1 [Myroides odoratus DSM 2801]
ATGTACCACTACTTTAGCAGTTTATTTGTACTGATTTTTTCTACTTTGGTCTATCCTCAATCGGATAAATTAAAAATTGAGCCGTTGAAC
GATCATATGTATGTCTATACGACCTACCAAGTATTTCAAGGCGTCGAATATTCTTCCAATGCTTTATATGTAGTGACGGATGAAGGAGTA
ATTCTCATTGATACCCCTTGGGATAAAGATCAGTACGCCCCTTTAGTAGAACACATCAGACGTGAACATAACAAAGAAATAAAATGGGTC
ATTACCACTCACTTCCACGAAGATCGTTCGGGTGGACTTGATTACTTCAATAAAGCTGGAGCAGAAACCTATACTTATGCTTTGACCAAC
GAAATCTTAAAACAGCGCAATGAACCACAAGCGACTTTTACTTTTGGTTCAACAAAGCAGTTCAACTTGGGCAAAGAAAAAATAGAGGTC
TATTTCTTAGGAGAAGGTCATAGTAAAGATAATACGGTGGTTTGGTTTCCAGAAGAAGCGATTTTATACGGTGGTTGTTTGATTAAAAGT
GCAGAGGCAACGACTATCGGCAATATCGTCGATGGCAATGTAGAGGCTTGGCCTACGACAATCAAAGCCGTAAAGCGCAAATTCAAAAAG
GCCAAAGTGATTATTCCAGGGCATGATGCCTGGAATCAATCCGGTCATCTTGAAAATACAGCCCGTATCTTATCGGCTTATCAGGCACAA
AAATTAAAGAACAACAAGCAATTATAA