MUS-2

Accession ARO:3003842
CARD Short NameMUS-2
DefinitionMUS-2 is a chromosome-encoded beta-lactamase from Myroides odoratimimus.
AMR Gene FamilyMUS beta-lactamase
Drug Classcarbapenem
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsMyroides odoratimimuswgs
Classification13 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic amoxicillin [Antibiotic]
+ confers_resistance_to_antibiotic piperacillin [Antibiotic]
+ confers_resistance_to_antibiotic ticarcillin [Antibiotic]
+ MUS beta-lactamase [AMR Gene Family]
Publications

Al-Bayssari C, et al. 2015. New Microbes New Infect 7:67-71 MUS-2, a novel variant of the chromosome-encoded β-lactamase MUS-1, from Myroides odoratimimus. (PMID 26257915)

Resistomes

Prevalence of MUS-2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Myroides odoratimimus0%0%8.33%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AKN19901.1|+|MUS-2 [Myroides odoratimimus]
MHRILSVITMLICTTLVHAQSDKLKIKQLNDNMYIYTTYQEFQGVTYSSNSMYVLTDEGAILIDTPWDKDQYEPLLEYIRSNHNKEVKWV
ITTHFHEDRSGGLGYFNSIGAQTYTYALTNEILKERNEPQAQYSFNKEKQFTFGNEKLAVYFLGEGHSLDNTVVWFPKEEVLYGGCLIKS
AEATTIGNIADGNVIAWPKTIEAVKQKFKNAKVIIPGHDEWDMIGHIENTERILSAYNQQHSTKND


>gb|KP658209.1|+|1-741|MUS-2 [Myroides odoratimimus]
ATGCACAGAATACTTAGTGTCATAACGATGTTAATCTGTACTACATTAGTACACGCTCAATCTGACAAGCTAAAAATCAAACAACTCAAT
GATAATATGTATATATACACTACTTATCAAGAGTTTCAAGGAGTAACATACTCTTCTAATTCGATGTACGTACTGACAGATGAAGGTGCT
ATTCTAATAGACACACCTTGGGATAAAGATCAGTACGAACCTCTATTAGAGTACATCAGATCGAATCATAACAAAGAGGTTAAATGGGTC
ATCACTACCCACTTCCACGAAGATCGTTCTGGTGGATTAGGTTACTTTAACAGTATAGGAGCACAGACGTATACCTATGCATTGACCAAT
GAAATATTAAAAGAACGCAATGAACCACAAGCTCAATATTCTTTTAATAAAGAAAAACAGTTTACCTTTGGCAATGAGAAGTTGGCTGTA
TACTTTTTAGGAGAAGGACATTCACTAGATAATACCGTAGTCTGGTTTCCAAAAGAAGAAGTACTATACGGAGGGTGCCTGATTAAGAGT
GCCGAAGCTACCACTATAGGTAATATAGCCGATGGTAACGTGATAGCTTGGCCTAAGACTATCGAAGCCGTAAAACAAAAATTTAAGAAT
GCTAAAGTCATTATACCAGGACATGATGAATGGGATATGATAGGGCATATCGAGAATACTGAGCGTATATTATCAGCATACAATCAACAA
CATTCAACTAAAAACGATTAA