| Accession | ARO:3007650 |
| CARD Short Name | CDA-1 |
| Definition | CDA-1 was recovered from a urine sample and is intermediate or resistant to third-generation cephalosporins and carbapenems. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC beta-lactamase expression combined with porin deficiency accounted for the carbapenem resistance. |
| AMR Gene Family | CDA beta-lactamase |
| Drug Class | penem, carbapenem, cephalosporin, cephamycin |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 24 ontology terms | Show + process or component of antibiotic biology or chemistry + resistance-modifying agents + inhibitor of antibiotic resistance mechanism + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + beta-lactamase inhibitor + beta-lactam antibiotic + hydrolysis of antibiotic conferring resistance + antibiotic inactivation enzyme + serine beta-lactamase inhibitor + cephem + beta-lactamase + beta-lactam derived beta-lactamase inhibitor + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + penem [Drug Class] + carbapenem [Drug Class] + cephalosporin [Drug Class] + class C beta-lactamase + antibiotic mixture + clavulanic acid [Adjuvant] + ticarcillin [Antibiotic] + cephamycin [Drug Class] |
| Parent Term(s) | 6 ontology terms | Show + CDA beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic cephaloridine [Antibiotic] + confers_resistance_to_antibiotic cefalotin [Antibiotic] + confers_resistance_to_antibiotic cefoxitin [Antibiotic] + confers_resistance_to_antibiotic ticarcillin [Antibiotic] + confers_resistance_to_antibiotic ticarcillin-clavulanic acid [Antibiotic+Adjuvant] |
| Publications | Ammenouche N, et al. 2014. Antimicrob Agents Chemother 58(11):6942-5 Characterization of a novel AmpC β-lactamase produced by a carbapenem-resistant Cedecea davisae clinical isolate. (PMID 25136020) |
Prevalence of CDA-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700