| Accession | ARO:3004129 |
| Synonym(s) | Cefaloridin Cefaloridine Cefalorizin Cephalomycine Cephaloridin Cephaloridinum Ceporin |
| Definition | Cephaloridine is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
| SMILES | O=C(Cc1cccs1)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12 |
| PubChem | 5773 |
| ChEMBL | CHEMBL316157 |
| ChEBI | 3537 |
| CAS | 50-59-9 |
| Drug Class | cephalosporin |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 4 ontology terms | Show + porin OmpC confers_resistance_to_antibiotic + CblA beta-lactamase [AMR Gene Family] confers_resistance_to_antibiotic + CblA-1 confers_resistance_to_antibiotic + CDA-1 confers_resistance_to_antibiotic |
| Publications | Reid AJ, et al. 1988. J. Pharm. Pharmacol. 40(8):571-3 Cephaloridine resistance in gram-negative bacteria isolated in Scotland. (PMID 2907014) Benner EJ, et al. 1965. J. Bacteriol. 90(6):1599-604 Inactivation of cephalothin and cephaloridine by Staphylococcus aureus. (PMID 5175748) |
| Curator | Description | Most Recent Edit |
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