| Accession | ARO:3004114 |
| CARD Short Name | porin_OmpC |
| Definition | In the presence of antibiotic stress, there is a coupled down-regulation of the porin OmpC with the OmpF. Mutants both lacking both OmpC and OmpF proteins are resistant to cephaloridine and cefazolin. Analyses of genes involved in the increased resistance to tetracycline suggest that the up-regulation of efflux pump genes is accompanied by a decrease of OmpF and OmpC synthesis. Homologs of OmpC have been identified in Escherichia coli, Salmonella enterica, Klebsiella aerogenes and Serratia marcescens. |
| AMR Gene Family | General Bacterial Porin with reduced permeability to beta-lactams |
| Drug Class | penem, penam, cephamycin, cephalosporin, carbapenem, monobactam |
| Resistance Mechanism | reduced permeability to antibiotic |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + beta-lactam antibiotic + determinant of antibiotic resistance + cephem + protein modulating permeability to antibiotic + General Bacterial Porin (GBP) + penem [Drug Class] + penam [Drug Class] + cephamycin [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic cefazolin [Antibiotic] + confers_resistance_to_antibiotic cephaloridine [Antibiotic] + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] |
| Publications | Viveiros M, et al. 2007. PLoS ONE 2(4):e365 Antibiotic stress, genetic response and altered permeability of E. coli. (PMID 17426813) Fernández L, et al. 2012. Clin. Microbiol. Rev. 25(4):661-81 Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. (PMID 23034325) Jaffe A, et al. 1982. Antimicrob. Agents Chemother. 22(6):942-8 Role of porin proteins OmpF and OmpC in the permeation of beta-lactams. (PMID 6760806) |
Prevalence of porin OmpC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein knockout model
Model Definition: Protein Knockout Models (PKM) reflect resistance by the absence of a gene product, most often deletion of a gene involved in antibiotic import, such as Vibrio cholerae OmpT. Like Protein Homolog Models (PHMs), PKMs include a reference sequence and a bitscore cut-off for detection using BLASTP but instead are designed to only report lack of detection under Perfect or Strict criteria. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software.
Bit-score Cut-off (blastP): 675
Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded