| Accession | ARO:3004122 |
| CARD Short Name | Kpne_OmpK37 |
| Definition | Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35. |
| AMR Gene Family | General Bacterial Porin with reduced permeability to beta-lactams |
| Drug Class | penem, penam, cephamycin, cephalosporin, carbapenem, monobactam |
| Resistance Mechanism | reduced permeability to antibiotic |
| Resistomes with Sequence Variants | Klebsiella aerogenesg, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + beta-lactam antibiotic + determinant of antibiotic resistance + cephem + protein modulating permeability to antibiotic + General Bacterial Porin (GBP) + penem [Drug Class] + penam [Drug Class] + cephamycin [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic cefoxitin [Antibiotic] + confers_resistance_to_antibiotic cefotaxime [Antibiotic] + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] |
| Publications | Doménech-Sánchez A, et al. 1999. J. Bacteriol. 181(9):2726-32 Identification and characterization of a new porin gene of Klebsiella pneumoniae: its role in beta-lactam antibiotic resistance. (PMID 10217760) |
Prevalence of Klebsiella pneumoniae OmpK37 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Klebsiella aerogenes | 2% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 98.7% | 0.03% | 56.48% | 0% |
| Klebsiella quasipneumoniae | 88.24% | 0% | 71.97% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700
Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded