| Accession | ARO:3004123 |
| CARD Short Name | Bpse_Omp38 |
| Definition | Heterologous expression of Burkholderia pseudomallei Omp38 (BpsOmp38) in Omp-deficient E. coli host cells lowers their permeability and in consequence, their antimicrobial susceptibility to penicillin G, cefoxitin, ceftazidime and imipenem. |
| AMR Gene Family | General Bacterial Porin with reduced permeability to beta-lactams |
| Drug Class | cephamycin, cephalosporin, penam, carbapenem, penem, monobactam |
| Resistance Mechanism | reduced permeability to antibiotic |
| Resistomes with Perfect Matches | Burkholderia malleig+wgs, Burkholderia pseudomalleig+wgs |
| Resistomes with Sequence Variants | Burkholderia malleig+wgs, Burkholderia oklahomensisg+wgs, Burkholderia pseudomalleig+wgs, Burkholderia thailandensisg+wgs |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + determinant of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + beta-lactam antibiotic + cephem + protein modulating permeability to antibiotic + cephamycin [Drug Class] + cephalosporin [Drug Class] + penam [Drug Class] + carbapenem [Drug Class] + General Bacterial Porin (GBP) + penem [Drug Class] + monobactam [Drug Class] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic cefoxitin [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic imipenem [Antibiotic] + confers_resistance_to_antibiotic benzylpenicillin [Antibiotic] + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] |
| Publications | Aunkham A, et al. 2014. PLoS ONE 9(5):e95918 Porin involvement in cephalosporin and carbapenem resistance of Burkholderia pseudomallei. (PMID 24788109) Siritapetawee J, et al. 2004. Biochem. J. 377(Pt 3):579-87 Functional reconstitution, gene isolation and topology modelling of porins from Burkholderia pseudomallei and Burkholderia thailandensis. (PMID 14567756) |
Prevalence of Burkholderia pseudomallei Omp38 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Burkholderia mallei | 50.85% | 0% | 55.95% | 0% |
| Burkholderia oklahomensis | 50% | 0% | 100% | 0% |
| Burkholderia pseudomallei | 49.48% | 0% | 86.03% | 0% |
| Burkholderia thailandensis | 50% | 0% | 73.58% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600
Type of Antibiotic Resistance: Acquired