TRU-1

Accession ARO:3004450
DefinitionA class C beta-lactamase enzyme identified from Aeromonas enteropelogenes. TRU-1 confers resistance to penicillin and cephalosporin antibiotics.
AMR Gene FamilyTRU beta-lactamase
Drug Classpenam, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification15 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ TRU beta-lactamase [AMR Gene Family]
Publications

De Luca F, et al. 2010. Antimicrob. Agents Chemother. 54(4):1547-54 Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. (PMID 20124004)

Resistomes

Prevalence of TRU-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 500


>gb|ABW05394.1|+|TRU-1 [Aeromonas enteropelogenes]
MKQRIALSLLALGPLLLVPRVYAAADEPMANIVEKAVQPLLEEYRIPGMAVAVLKEGKPHYFNYGVANRESGRRISERTLFEIGSVSKTF
TATLGTYAVVKGGFRLDDKVSQHAPWLQNSAFDRVTMAQLATYSAGGLPLQFPDAVDSNERMRQYYRQWSPLYAAGTHREYSNPSIGLFG
HLAASTLGQPFRQLMSQTLLPKLDLQHTYLEVPDAAMVDYAYGYSKEDKPVRVNPGVLADEAYGIKTSAADLIKFVGANMTGSGDKAVQQ
ALAMTRTGFYSVGEMTQGLGWESYAYPVTEQALLAGNSPAVSFKANPVKPFVAPRVMGNERLYNKTGSTNGFGAYVVFVPARGVGIVMLA
NRNYPIEARVKAAYAIMRHLAP


>gb|EU046614.1|+|1-1149|TRU-1 [Aeromonas enteropelogenes]
ATGAAACAACGAATCGCGCTATCACTGCTGGCATTGGGGCCCCTGTTGCTCGTCCCACGCGTTTATGCCGCGGCAGATGAGCCCATGGCG
AACATAGTGGAAAAGGCTGTCCAGCCGCTGCTGGAGGAGTACCGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGAGGGCAAGCCTCAC
TACTTCAATTATGGCGTCGCCAATCGGGAGAGCGGCCGGCGCATCAGCGAGCGGACCCTGTTCGAGATTGGTTCGGTCAGCAAGACCTTT
ACTGCGACCTTGGGCACCTACGCGGTCGTCAAAGGGGGCTTTCGGCTGGATGACAAGGTGAGCCAGCACGCGCCTTGGTTGCAGAATTCG
GCGTTTGATCGCGTCACCATGGCCCAGCTGGCGACCTACAGCGCAGGGGGCTTGCCGTTGCAGTTTCCCGATGCGGTCGACTCAAACGAG
AGAATGCGCCAGTACTACCGGCAGTGGTCACCGCTTTATGCGGCAGGCACTCATCGCGAGTACTCCAACCCCAGCATAGGTCTGTTCGGC
CATCTGGCGGCGAGCACCCTGGGCCAACCATTCAGACAACTGATGAGCCAGACTCTGCTGCCCAAGCTCGATTTGCAGCACACCTATCTC
GAGGTGCCAGACGCAGCCATGGTTGACTACGCCTATGGCTATTCGAAGGAAGACAAACCCGTCAGGGTCAATCCCGGAGTGCTGGCGGAC
GAAGCCTATGGCATCAAGACCAGCGCGGCGGATCTCATCAAGTTTGTGGGCGCCAACATGACAGGCAGTGGCGACAAGGCGGTGCAGCAA
GCGCTGGCCATGACCCGTACCGGTTTCTACTCGGTGGGAGAGATGACCCAGGGGCTGGGGTGGGAGAGCTACGCCTATCCCGTGACCGAA
CAGGCGCTGCTGGCGGGCAATTCACCGGCGGTGAGCTTCAAGGCCAATCCGGTCAAACCCTTTGTGGCTCCCAGAGTGATGGGGAACGAG
CGACTCTACAACAAGACAGGCTCGACCAACGGCTTTGGTGCCTATGTGGTGTTTGTCCCGGCCAGAGGCGTGGGCATCGTCATGCTGGCC
AATCGCAACTACCCCATCGAGGCCAGGGTCAAGGCTGCCTATGCCATCATGCGCCATCTGGCACCCTGA