PRC-1

Accession ARO:3007085
CARD Short NamePRC-1
DefinitionPRC-1 is a beta-lactamase that confers resistance to certain cephalosporins and penicillins.
AMR Gene FamilyPRC beta-lactamase
Drug Classpenicillin beta-lactam, cephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsPseudomonas aeruginosawgs, Pseudomonas mendocinag+wgs
Classification17 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ confers_resistance_to_antibiotic cefazolin [Antibiotic]
+ confers_resistance_to_antibiotic ceftriaxone [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin [Antibiotic]
+ confers_resistance_to_antibiotic benzylpenicillin [Antibiotic]
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic cefotaxime [Antibiotic]
+ PRC beta-lactamase [AMR Gene Family]
Publications

Zhang P, et al. 2021. Front Microbiol 12:732932 Characterization of a Novel Chromosome-Encoded AmpC β-Lactamase Gene, bla PRC-1, in an Isolate of a Newly Classified Pseudomonas Species, Pseudomonas wenzhouensis A20, From Animal Farm Sewage. (PMID 34975778)

Resistomes

Prevalence of PRC-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Pseudomonas aeruginosa0%0%0.01%0%0%
Pseudomonas mendocina87.5%0%100%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 600


>gb|QTV22830.1|+|PRC-1 [Pseudomonas wenzhouensis]
MRHLYRPLFVALALLAASHAPAAPSLETQVDAAAKSMMQTHAIPGMAIAISHKGQSHFFEYGVASLENGQTVDRHTLFELGSISKLFTAT
LGAYAEARGTLNLSDNASQYLPALQGSAFDHISLLDLATYTSGGLPLQFPDTVSNERQMLDYYRNWQAVYPPGTQRLYSNPSIGLFGHLA
AASLAKPFQQLMEKDLLPQLSMQESYVRIPTEQMEHYAWGYRDDKAVRVTPGALDAEAYGLKSTAADVLRFIDANLHPDQLPAPLRQAIS
ATHRGYYQVGDMTQALGWERYAYPISLEKLQAGNSAEMALQPQTVARFAAPKPAEGDLLLNKTGSTNGFGAYILLLPARDTGLVILANRN
YPNAERVRLALQLLDAIEP


>gb|MW854031.1|+|1-1140|PRC-1 [Pseudomonas wenzhouensis]
ATGCGCCACCTGTACCGCCCTCTGTTCGTCGCCCTGGCGCTGCTGGCCGCCAGCCACGCGCCGGCCGCACCTTCACTGGAAACACAGGTG
GACGCCGCTGCGAAGTCGATGATGCAGACCCATGCCATTCCCGGCATGGCCATCGCCATCAGCCACAAGGGGCAGTCGCATTTCTTCGAA
TACGGCGTCGCATCCCTTGAAAACGGCCAGACGGTGGATCGCCATACCCTTTTCGAGCTGGGCTCGATCAGCAAACTCTTCACCGCCACC
CTCGGCGCCTACGCCGAAGCGCGCGGCACGCTGAACCTCAGTGACAACGCCAGCCAGTATCTGCCGGCCCTGCAGGGCAGCGCCTTCGAT
CACATCAGTTTGCTGGATCTGGCCACTTACACCTCGGGCGGCCTGCCACTGCAGTTCCCGGACACGGTCAGCAACGAACGGCAGATGCTC
GATTACTACCGCAACTGGCAGGCGGTGTATCCGCCGGGTACGCAGCGGCTGTATTCCAACCCCAGCATCGGCCTGTTCGGCCACCTGGCA
GCAGCCAGTCTGGCCAAGCCGTTTCAGCAGTTGATGGAGAAGGATCTGCTGCCGCAACTGAGCATGCAGGAAAGCTACGTCCGTATACCG
ACCGAGCAGATGGAGCACTATGCCTGGGGCTACCGCGACGACAAGGCGGTGCGCGTGACGCCCGGCGCGCTGGATGCCGAAGCCTACGGG
TTGAAATCTACTGCCGCCGACGTGCTACGCTTCATCGACGCCAATCTGCACCCGGATCAACTACCCGCACCACTGCGCCAGGCGATCAGC
GCAACACATCGTGGCTACTACCAGGTCGGCGACATGACTCAGGCGCTGGGCTGGGAGCGCTACGCCTACCCCATCAGCCTAGAAAAACTG
CAGGCTGGCAACTCAGCAGAAATGGCGCTGCAACCGCAGACCGTGGCGCGTTTCGCTGCGCCCAAGCCTGCCGAAGGTGACCTGCTGCTG
AACAAGACCGGCTCGACCAACGGCTTCGGCGCCTACATCCTACTGCTGCCGGCGCGCGATACCGGCCTGGTGATACTCGCCAACCGCAAT
TACCCCAATGCCGAACGCGTGCGCCTGGCCTTGCAATTGCTGGACGCGATCGAGCCGTAG

Curator Acknowledgements
Curator Description Most Recent Edit