| Accession | ARO:3000057 |
| Definition | NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins. |
| Drug Class | carbapenem, penam, cephamycin, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + hydrolysis of antibiotic conferring resistance + antibiotic molecule + antibiotic inactivation enzyme + beta-lactamase + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactam antibiotic + cephem + class B (metallo-) beta-lactamase |
| Parent Term(s) | 5 ontology terms | Show + subclass B1 (metallo-) beta-lactamase + confers_resistance_to_drug_class carbapenem [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_drug_class cephamycin [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] |
| Sub-Term(s) | 47 ontology terms | Show + NDM-1 + NDM-2 + NDM-5 + NDM-3 + NDM-4 + NDM-6 + NDM-7 + NDM-8 + NDM-9 + NDM-10 + NDM-11 + NDM-12 + NDM-13 + NDM-14 + NDM-15 + NDM-16a + NDM-17 + NDM-18 + NDM-19 + NDM-20 + NDM-21 + NDM-22 + NDM-23 + NDM-24 + NDM-25 + NDM-26 + NDM-27 + NDM-28 + NDM-29 + NDM-30 + NDM-31 + NDM-33 + NDM-16b + NDM-34 + NDM-35 + NDM-36 + NDM-37 + NDM-38 + NDM-39 + NDM-40 + NDM-41 + NDM-42 + NDM-43 + NDM-44 + NDM-45 + NDM-46 + NDM-47 |
| Publications | Kumarasamy KK, et al. 2010. Lancet Infect Dis 10(9): 597-602. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. (PMID 20705517) Kus JV, et al. 2011. CMAJ 183(11): 1257-1261. New Delhi metallo-{beta}-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. (PMID 21624908) Nordmann P, et al. 2011. J Antimicrob Chemother 66(4): 689-692. Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?. (PMID 21393184) Hornsey M, et al. 2011. Antimicrob Agents Chemother 55(12): 5952-5954. A Novel Variant, NDM-5, of the New Delhi Metallo-beta-Lactamase in a Multidrug-Resistant Escherichia coli ST648 Isolate Recovered from a Patient in the United Kingdom. (PMID 21930874) Nordmann P, et al. 2011. Trends Microbiol 19(12): 588-595. The emerging NDM carbapenemases. (PMID 22078325) Zhang H and Hao Q. 2011. FASEB J 25(8): 2574-2582. Crystal structure of NDM-1 reveals a common {beta}-lactam hydrolysis mechanism. (PMID 21507902) Paget JT, et al. 2014. J Burn Care Res 35(2): E125-E127. Keeping New Delhi metallo-beta-lactamase-1 at the door. (PMID 24165671) Yong D, et al. 2009. Antimicrob Agents Chemother 53(12): 5046-5054. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. (PMID 19770275) |