NDM beta-lactamase [AMR Gene Family]

Accession ARO:3000057
DefinitionNDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins.
Drug Classcarbapenem, penam, cephamycin, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ subclass B1 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephamycin [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
47 ontology terms | Show

Kumarasamy KK, et al. 2010. Lancet Infect Dis 10(9): 597-602. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. (PMID 20705517)

Kus JV, et al. 2011. CMAJ 183(11): 1257-1261. New Delhi metallo-{beta}-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. (PMID 21624908)

Nordmann P, et al. 2011. J Antimicrob Chemother 66(4): 689-692. Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?. (PMID 21393184)

Hornsey M, et al. 2011. Antimicrob Agents Chemother 55(12): 5952-5954. A Novel Variant, NDM-5, of the New Delhi Metallo-beta-Lactamase in a Multidrug-Resistant Escherichia coli ST648 Isolate Recovered from a Patient in the United Kingdom. (PMID 21930874)

Nordmann P, et al. 2011. Trends Microbiol 19(12): 588-595. The emerging NDM carbapenemases. (PMID 22078325)

Zhang H and Hao Q. 2011. FASEB J 25(8): 2574-2582. Crystal structure of NDM-1 reveals a common {beta}-lactam hydrolysis mechanism. (PMID 21507902)

Paget JT, et al. 2014. J Burn Care Res 35(2): E125-E127. Keeping New Delhi metallo-beta-lactamase-1 at the door. (PMID 24165671)

Yong D, et al. 2009. Antimicrob Agents Chemother 53(12): 5046-5054. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. (PMID 19770275)