Accession ARO:3000590
CARD Short NameNDM-2
DefinitionNDM-2 was isolated from a strain of Acinetobacter baumannii in Germany from a patient hospitalized in Cairo. A single amino acid substitution (P28R) differentiates this gene from NDM-1 and the two enzymes appear to have an identical spectrum of hydrolysis.
AMR Gene FamilyNDM beta-lactamase
Drug Classpenam, cephalosporin, carbapenem, cephamycin
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+wgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+wgs
Classification17 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ NDM beta-lactamase [AMR Gene Family]
1 ontology terms | Show
+ taniborbactam [Adjuvant] is_small_molecule_inhibitor

Kaase M, et al. 2011. J Antimicrob Chemother 66(6): 1260-1262. NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. (PMID 21427107)


Prevalence of NDM-2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0.18%0%0.03%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500

>gb|AEA41876.1|+|NDM-2 [Acinetobacter baumannii]

>gb|JF703135.1|+|1-813|NDM-2 [Acinetobacter baumannii]