| Accession | ARO:3002357 |
| CARD Short Name | NDM-7 |
| Definition | NDM-7 is a beta-lactamase found in Escherichia coli. |
| AMR Gene Family | NDM beta-lactamase |
| Drug Class | cephalosporin, cephamycin, carbapenem, penam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Providencia rettgeriwgs, Salmonella entericap+wgs |
| Resistomes with Sequence Variants | Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Providencia rettgeriwgs, Salmonella entericap+wgs |
| Classification | 17 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactamase + cephem + class B (metallo-) beta-lactamase + cephalosporin [Drug Class] + cephamycin [Drug Class] + carbapenem [Drug Class] + subclass B1 (metallo-) beta-lactamase + penam [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + NDM beta-lactamase [AMR Gene Family] |
| Publications | Gottig S, et al. 2013. J Antimicrob Chemother 68(8): 1737-1740. Detection of NDM-7 in Germany, a new variant of the New Delhi metallo-beta-lactamase with increased carbapenemase activity. (PMID 23557929) |
Prevalence of NDM-7 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter freundii | 0% | 0% | 0.19% | 0% |
| Citrobacter portucalensis | 0% | 0% | 0.9% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.3% | 0% |
| Escherichia coli | 0% | 0.01% | 0.06% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.09% | 0.2% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.42% | 0.79% | 0% |
| Providencia rettgeri | 0% | 0% | 2.55% | 0% |
| Salmonella enterica | 0% | 0.05% | 0.01% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500