SIM beta-lactamase [AMR Gene Family]

Accession ARO:3004206
DefinitionSIM beta-lactamases are Class B beta-lactamases that are capable of hydrolyzing a wide variety of beta-lactams, including penicillins, narrow- to expanded-spectrum cephalosporins, and carbapenem. The SIM family of beta-lactamases appear to be transferable through integrons.
Drug Classpenam, carbapenem, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ subclass B1 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
2 ontology terms | Show

Lee K, et al. 2005. Antimicrob Agents Chemother 49(11): 4485-4491. Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea. (PMID 16251286)

Valenza G, et al. 2010. Antimicrob. Agents Chemother. 54(8):3493-7 First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. (PMID 20498315)