TMB beta-lactamase [AMR Gene Family]

Accession ARO:3004104
DefinitionTMB-1, the first known member of the Tripoli metallo-beta-lactamase family (TMB) was isolated from Achromobacter xylosoxidans in a Tripoli central hospital. TMB-1 was located on a class 1 integron and is a chromosomally-encoded beta-lactamase capable of hydrolyzing multiple antibiotics.
Drug Classcarbapenem, cephalosporin, cephamycin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ subclass B1 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class cephamycin [Drug Class]
2 ontology terms | Show

El Salabi A, et al. 2012. Antimicrob. Agents Chemother. 56(5):2241-5 Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya. (PMID 22290947)