Subclass B1 Vibrio cholerae varG beta-lactamase [AMR Gene Family]

Accession ARO:3004288
DefinitionvarG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro.
Drug Classcarbapenem
Resistance Mechanismantibiotic inactivation
Classification11 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ subclass B1 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class carbapenem [Drug Class]
1 ontology terms | Show

Lin HV, et al. 2017. PLoS ONE 12(9):e0184255 The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor. (PMID 28898293)