| Accession | ARO:3004289 |
| CARD Short Name | Vcho_varG |
| Definition | varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. Described by Lin HV et al. 2017. |
| AMR Gene Family | Subclass B1 Vibrio cholerae varG beta-lactamase |
| Drug Class | carbapenem |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Vibrio choleraeg+wgs |
| Resistomes with Sequence Variants | Vibrio choleraeg+wgs, Vibrio metoecusg+wgs, Vibrio mimicusg+wgs, Vibrio vulnificusg+wgs |
| Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactamase + antibiotic molecule + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactam antibiotic + class B (metallo-) beta-lactamase + carbapenem [Drug Class] + subclass B1 (metallo-) beta-lactamase |
| Parent Term(s) | 2 ontology terms | Show + Subclass B1 Vibrio cholerae varG beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic meropenem [Antibiotic] |
| Publications | Lin HV, et al. 2017. PLoS ONE 12(9):e0184255 The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor. (PMID 28898293) |
Prevalence of Vibrio cholerae varG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Vibrio cholerae | 41.7% | 0% | 56.74% | 0% |
| Vibrio metoecus | 25% | 0% | 16% | 0% |
| Vibrio mimicus | 50% | 0% | 100% | 0% |
| Vibrio vulnificus | 49.09% | 0% | 74.69% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500