| Accession | ARO:3003807 |
| CARD Short Name | Ecol_AcrR_MULT |
| Definition | AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic, disinfecting agents and antiseptics, rifamycin antibiotic, penam, glycylcycline, phenicol antibiotic, cephalosporin, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic target alteration, antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Sequence Variants | Citrobacter koserig+wgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Escherichia marmotaeg+wgs, Salmonella entericawgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs |
| Classification | 30 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + antibiotic target alteration [Resistance Mechanism] + cephem + antibiotic efflux [Resistance Mechanism] + tetracycline antibiotic [Drug Class] + determinant of antibiotic resistance + disinfecting agents and antiseptics [Drug Class] + rifamycin antibiotic [Drug Class] + penam [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + glycylcycline [Drug Class] + phenicol antibiotic [Drug Class] + mutation conferring antibiotic resistance + cephalosporin [Drug Class] + cefalotin [Antibiotic] + ampicillin [Antibiotic] + chloramphenicol [Antibiotic] + tetracycline [Antibiotic] + fluoroquinolone antibiotic [Drug Class] + antibiotic resistant gene variant or mutant + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + tigecycline [Antibiotic] + triclosan [Antibiotic] + rifampin [Antibiotic] + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + mutant efflux regulatory protein conferring antibiotic resistance + AcrAB-TolC |
| Parent Term(s) | 4 ontology terms | Show + acrR + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] |
| Publications | Webber MA, et al. 2005. Antimicrob. Agents Chemother. 49(10):4390-2 Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates. (PMID 16189130) |
Prevalence of Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter koseri | 100% | 0% | 49.55% | 0% |
| Escherichia albertii | 100% | 0% | 62.58% | 0% |
| Escherichia coli | 65.2% | 0.01% | 60.32% | 0% |
| Escherichia fergusonii | 100% | 0.36% | 50% | 0% |
| Escherichia marmotae | 100% | 0% | 68.75% | 0% |
| Salmonella enterica | 0% | 0% | 0.01% | 0% |
| Shigella boydii | 100% | 0% | 96.67% | 0% |
| Shigella dysenteriae | 100% | 0% | 100% | 0% |
| Shigella flexneri | 99% | 0% | 81.83% | 0% |
| Shigella sonnei | 100% | 0% | 93.94% | 0% |
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein overexpression model
Model Definition: Protein Overexpression Models (POM) are similar to Protein Variant Models (PVM) in that they include a protein reference sequence, a curated BLASTP bitscore cut-off, and mapped resistance variants. Whereas PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, reporting only those with curated mutations conferring AMR, POMs are restricted to regulatory proteins and report both wild-type sequences and/or sequences with mutations leading to overexpression of efflux complexes. The former lead to efflux of antibiotics at basal levels, while the latter can confer clinical resistance. POMs include a protein reference sequence (often from wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Perfect RGI match is 100% identical to the wild-type reference protein sequence along its entire length, a Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value may or may not contain at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off may or may not contain at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 375
Legend:
Published Variants:
| PMID: 16189130 | R45C |
Model Name: E. coli AcrAB-TolC with AcrR mutation conferring resistance to cirpofloxacin
Model Description: AcrR is the repressor of the AcrAB operon, where a mutation in AcrR allows AcrAB-TolC to confer resistance to ciprofloxacin.
TolCacrBEscherichia coli acrR with mutation conferring multidrug antibiotic resistanceEscherichia coli acrA