Accession ARO:3000702
DefinitionAcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, disinfecting agents and antiseptics, glycylcycline, cephalosporin, penam, rifamycin antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux, antibiotic target alteration
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification27 ontology terms | Show
Parent Term(s)3 ontology terms | Show
3 ontology terms | Show

Pradel E and Pages JM. 2002. Antimicrob Agents Chemother 46(8): 2640-2643. The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes. (PMID 12121946)