| Accession | ARO:3000907 |
| Synonym(s) | IRT-8 |
| CARD Short Name | TEM-37 |
| Definition | TEM-37 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. |
| AMR Gene Family | TEM beta-lactamase |
| Drug Class | penam, cephalosporin, monobactam, penem |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Escherichia colip |
| Resistomes with Sequence Variants | Escherichia colip |
| Classification | 17 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + antibiotic inactivation enzyme + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + penam [Drug Class] + cephalosporin [Drug Class] + monobactam [Drug Class] + ampicillin [Antibiotic] + class A beta-lactamase + penem [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Henquell C, et al. 1995. Antimicrob Agents Chemother 39(2): 427-430. Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli. (PMID 7726509) Kempf F, et al. 2016. PLoS One 11(1):e0147954 Genomic Comparative Study of Bovine Mastitis Escherichia coli. (PMID 26809117) |
Prevalence of TEM-37 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Escherichia coli | 0% | 0.01% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500