Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam

Accession ARO:3007421
CARD Short NameKpne_PBP3_BLA
DefinitionMutant PBP3 in Klebsiella pneumoniae conferring resistance to ceftazidime-avibactam.
AMR Gene FamilyPenicillin-binding protein mutations conferring resistance to beta-lactam antibiotics
Drug Classpenam, cephalosporin, cephamycin
Resistance Mechanismantibiotic target alteration
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics [AMR Gene Family]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
Publications

Guo Y, et al. 2021. Emerg Microbes Infect 10(1):2042-2051 Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae. (PMID 34551677)

Resistomes

Prevalence of Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 1100

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:


>gb|CDO16001.1|-|Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam [Klebsiella pneumoniae]
MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMR
SLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMP
LDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIG
FTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERL
QALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAIT
DVFEPGSTVKPMVVMTALQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSS
NVGVSKLALAMPSSVLVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYG
LMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGG
GVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKY
YGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS



>gb|FO834906.1|-|4514345-4516111|Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam [Klebsiella pneumoniae]
ATGAAAGCAGCGCCAAAAACGCCTAAAGCAAAACGTCAGGAAGAACAGGCCAACTTTATCAGTTGGCGTTTTGCGTTGCTGTGCGGCTGT
ATTCTGCTGGCGCTGGCTTTTCTGCTGGGTCGCGTCGCCTGGCTACAGGTGATCAGCCCCGATATGCTGGTGCGCCAGGGCGATATGCGT
TCTTTGCGCGTACAGGAAGTGTCCACCGCGCGCGGGATGATTACCGATCGCTCCGGACGTCCGCTGGCGGTCAGCGTGCCGGTGAAGGCT
ATCTGGGCCGACCCGAAAGAGCTCCATGACGCCGGTGGGGTTACCCTGGATACGCGCTGGAAAGCGCTGGCGGATGCCCTCAATATGCCG
CTGGATCAGCTGGCGACGCGCATCAATACCAATCCGCGGATGCGGTTTATCTATCTGGCGCGTCAGGTTAATCCTGACATGGCCGATTAC
ATCAAGAAGCTGAAGCTGCCGGGCATTCATCTGCGCGAAGAATCCCGTCGTTACTACCCTTCCGGGGAAGTAACCGCTCACCTCATCGGC
TTTACCAACGTCGATAGCCAGGGGATTGAAGGGGTTGAGAAAAGCTTTGATAAATGGCTTACCGGTCAGCCGGGCGAGCGTATCGTACGT
AAAGACCGCTATGGCCGGGTAATTGAAGACATCTCTTCTACCGATAGCCAGGCAGCGCACAACCTGGCGCTGAGTATCGACGAACGCCTG
CAGGCGCTGGTCTATCGCGAGCTGAACAACGCCGTGGCCTTTAACAAAGCCGAGTCGGGCAGCGCCGTGTTAGTGGATGTTAACACCGGT
GAAGTGCTGGCGATGGCCAACAGCCCATCCTATAACCCGAACAACTTCGCCGGTACGGCAAAAGACACCATGCGTAACCGTGCGATTACC
GACGTGTTTGAGCCGGGTTCGACGGTGAAACCGATGGTGGTCATGACGGCGCTGCAGCGCGGTATCGTCAACGAAAATACCGTGCTCAAT
ACCGTGCCTTATCGAATTAACGGCCACGAAATCAAAGACGTGGCGCGCTACAGCGAATTGACCCTGACCGGGGTGCTACAGAAGTCGAGT
AACGTCGGTGTTTCTAAGCTGGCGTTAGCGATGCCGTCCTCAGTGTTAGTAGATACTTACTCACGTTTTGGGCTTGGAAAGGCGACCAAT
TTGGGGTTGGTCGGAGAACGCAGTGGCTTATATCCTCAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTTTCTTTCGGCTATGGG
CTAATGGTAACCCCGTTACAGTTAGCGCGAGTCTACGCAACGATTGGCAGCTATGGCATCTATCGCCCGTTGTCGATTACCAAGGTTGAT
CCTCCGGTTCCGGGCGAGCGCGTCTTCCCGGAATCACTCGTTCGTACCGTCGTTCATATGATGGAAAGCGTGGCGCTGCCCGGCGGCGGC
GGTGTGAAAGCGGCGATCAAAGGCTATCGCATCGCGATTAAAACCGGTACGGCGAAAAAAGTGGGGCCGGATGGCCGCTATATCAACAAA
TATATTGCTTACACCGCAGGCGTTGCGCCCGCCAGCCATCCGCGCTTCGCGCTGGTGGTGGTGATCAACGACCCGCAGGCAGGTAAATAC
TACGGTGGCGCCGTTTCCGCGCCGGTCTTCGGTGCCATCATGGGCGGCGTATTGCGCACCATGAACATCGAGCCGGATGCGCTGGCAACG
GGCGAAAAAAGTGAATTTGTAATTAATCAAGGCGAGGGAACAGGTGGCAGATCGTAA