OXA-23

Accession ARO:3001418
Synonym(s)ARI-1
CARD Short NameOXA-23
DefinitionOXA-23 is a beta-lactamase found in A. baumannii.
AMR Gene FamilyOXA beta-lactamase, OXA-23-like beta-lactamase
Drug Classpenam, carbapenem
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+p+wgs+gi, Acinetobacter indicuswgs, Acinetobacter johnsoniip, Acinetobacter nosocomialisg+wgs, Acinetobacter pittiiwgs, Acinetobacter radioresistenswgs, Acinetobacter wuhouensisp, Escherichia colig, Proteus mirabilisg+wgs+gi
Resistomes with Sequence VariantsAcinetobacter baumanniig+p+wgs+gi, Acinetobacter indicuswgs, Acinetobacter johnsoniip, Acinetobacter nosocomialisg+p+wgs, Acinetobacter pittiiwgs, Acinetobacter radioresistenswgs, Acinetobacter wuhouensisp, Escherichia colig, Proteus mirabilisg+wgs+gi
Classification15 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ OXA-23-like beta-lactamase [AMR Gene Family]
Sub-Term(s)
3 ontology terms | Show
+ BLI-489 [Adjuvant] is_small_molecule_inhibitor
+ ANT3310 [Adjuvant] is_small_molecule_inhibitor
+ Xeruborbactam [Adjuvant] is_small_molecule_inhibitor
Publications

Donald HM, et al. 2000. Antimicrob Agents Chemother 44(1): 196-199. Sequence analysis of ARI-1, a novel OXA beta-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92. (PMID 10602749)

Resistomes

Prevalence of OXA-23 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii45.84%2.86%39.94%6.29%
Acinetobacter indicus0%0%2.6%0%
Acinetobacter johnsonii0%1.39%0%0%
Acinetobacter nosocomialis9.09%1.64%1.72%0%
Acinetobacter pittii0%0%1.7%0%
Acinetobacter radioresistens0%0%22.81%0%
Acinetobacter wuhouensis0%4.55%0%0%
Escherichia coli0.02%0%0%0%
Proteus mirabilis3.67%0%3.63%3.7%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AAV65289.1|+|OXA-23 [Acinetobacter baumannii]
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGL
ENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEF
VSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQL
NII


>gb|AY795964.1|+|1-822|OXA-23 [Acinetobacter baumannii]
ATGAATAAATATTTTACTTGCTATGTGGTTGCTTCTCTTTTTCTTTCTGGTTGTACGGTTCAGCATAATTTAATAAATGAAACCCCGAGT
CAGATTGTTCAAGGACATAATCAGGTGATTCATCAATACTTTGATGAAAAAAACACCTCAGGTGTGCTGGTTATTCAAACAGATAAAAAA
ATTAATCTATATGGTAATGCTCTAAGCCGCGCAAATACAGAATATGTGCCAGCCTCTACATTTAAAATGTTGAATGCCCTGATCGGATTG
GAGAACCAGAAAACGGATATTAATGAAATATTTAAATGGAAGGGCGAGAAAAGGTCATTTACCGCTTGGGAAAAAGACATGACACTAGGA
GAAGCCATGAAGCTTTCTGCAGTCCCAGTCTATCAGGAACTTGCGCGACGTATCGGTCTTGATCTCATGCAAAAAGAAGTAAAACGTATT
GGTTTCGGTAATGCTGAAATTGGACAGCAGGTTGATAATTTCTGGTTGGTAGGACCATTAAAGGTTACGCCTATTCAAGAGGTAGAGTTT
GTTTCCCAATTAGCACATACACAGCTTCCATTTAGTGAAAAAGTGCAGGCTAATGTAAAAAATATGCTTCTTTTAGAAGAGAGTAATGGC
TACAAAATTTTTGGAAAGACTGGTTGGGCAATGGATATAAAACCACAAGTGGGCTGGTTGACCGGCTGGGTTGAGCAGCCAGATGGAAAA
ATTGTCGCTTTTGCATTAAATATGGAAATGCGGTCAGAAATGCCGGCATCTATACGTAATGAATTATTGATGAAATCATTAAAACAGCTG
AATATTATTTAA