| Accession | ARO:3002314 |
| CARD Short Name | KPC-4 |
| Definition | KPC-4 is a beta-lactamase found in Klebsiella pneumoniae. |
| AMR Gene Family | KPC beta-lactamase |
| Drug Class | penicillin beta-lactam, cephalosporin, carbapenem, monobactam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter amalonaticuswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Escherichia colip+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Serratia marcescenswgs |
| Resistomes with Sequence Variants | Citrobacter amalonaticuswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Escherichia colip+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Serratia marcescenswgs |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactam antibiotic + beta-lactamase + class A beta-lactamase + penicillin beta-lactam [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + KPC beta-lactamase [AMR Gene Family] |
| Sub-Term(s) | 1 ontology terms | Show + relebactam [Adjuvant] is_small_molecule_inhibitor |
| Publications | Wolter DJ, et al. 2009. Antimicrob Agents Chemother 53(2): 557-562. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. (PMID 19015357) |
Prevalence of KPC-4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Citrobacter amalonaticus | 0% | 0% | 1.82% | 0% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 0.64% | 0% | 0% |
| Enterobacter hormaechei | 0% | 0.51% | 1.12% | 0% | 0% |
| Escherichia coli | 0% | 0.01% | 0.01% | 0% | 0% |
| Klebsiella michiganensis | 0% | 1.71% | 1.33% | 0% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% | 0% |
| Klebsiella pneumoniae | 0.12% | 0.01% | 0.05% | 0% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.53% | 0% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 550
| Curator | Description | Most Recent Edit |
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